钙剂在预防机采血小板时不良反应的作用观察

Observation on the Effect of Calcium Agents in preventing adverse Reactions during Platelet Collection by Machine

目的 探究钙剂在预防机采血小板时不良反应的作用情况。方法 选择我市中心血站体2021年6月至2021年12月期间采集的206名献血志愿者作为研究对象,并将其随机数字表法分为两组,各103名,对照组在采血期间不给予钙剂补充,实验组予以钙剂补充治疗,比较两组志愿者在不同时间点的血清钙和镁的含量、甲状旁腺激素水平、骨代谢情况(骨钙素、β-胶原特殊序列以及碱性磷酸酶)、不良反应发生情况。结果 机采中、后,实验组患者血清钙、镁含量均高于对照组,差异有统计学意义(P<0.05);甲状旁腺激素水平低于对照组,差异有统计学意义(P<0.05);与对照组相比,机采后,实验组骨钙素、碱性磷酸酶以及β-胶原特殊序水平均较低,但仅有β-胶原特殊序,差异有统计学意义(P<0.05);实验组患者不良反应发生率为2.91%,低于对照组9.71%,差异有统计学意义(P<0.05)。结论 在机采血小板志愿者中给予其钙剂补充,可有效促进血清钙、镁以及甲状旁腺激素水平波动稳定,减少不良反应发生,促进其骨代谢平衡。

Objective To investigate the role of calcium agents in preventing adverse reactions during platelet collection.Methods A total of 206 blood donation volunteers from the Blood Collection Department of our city center from June 2021 to December 2021 were selected as the research subjects,and they were divided into two groups with 103 volunteers each according to the random number table.The control group did not receive calcium supplementation during the blood collection period,while the experimental group received calcium supplementation treatment.The serum calcium and magnesium levels,parathyroid hormone levels,and bone metabolism(osteocalcin,β-collagen specific sequences and alkaline phosphatase) of the two groups of volunteers at different time points were compared,as well as the occurrence of adverse reactions.Results s During and after machine harvesting,the serum calcium and magnesium levels in the experimental group were higher than those in the control group,with a statistically significant difference(P<0.05);The level of parathyroid hormone was lower than that of the control group,and the difference was statistically significant(P<0.05);Compared with the control group,after mechanical harvesting,the experimental group showed osteocalcin,alkaline phosphatase,and β-The average collagen specific sequence water is low,but only β-collagen specific sequence,with statistically significant differences(P<0.05);The incidence of adverse reactions in the experimental group was 2.91%,lower than 9.71% in the control group,with a statistically significant difference(P<0.05).Conclusion Supplementing with calcium supplements in mechanically collected platelet volunteers can effectively promote stable fluctuations in serum calcium,magnesium,and parathyroid hormone levels,reduce adverse reactions,and promote bone metabolism balance.