龙胆化学成分、生物活性及临床应用研究进展

Research progress on chemical constituents,biological activities and clinical applications of Gentianae Radix et Rhizoma

龙胆Gentianae Radix et Rhizoma具有清热燥湿、泻肝胆火的功效。龙胆主要含有环烯醚萜类、三萜类、[口山]酮类及黄酮类等化学成分,具有抗炎镇痛、保肝、抗肿瘤、调节胃肠功能、调节神经系统等作用,临床上广泛应用于带状疱疹、高血压、突发性耳聋及各类炎症性疾病。通过对龙胆的化学成分、生物活性和临床应用进行综述,为其进一步开发和应用提供理论参考和科学依据。

Longdan(Gentianae Radix et Rhizoma)has the effects of clearing heat and drying dampness,and purging fire in the liver and gallbladder.Chemical compounds isolated and identified from this plant included iridoids,triterpenes,xanthones and flavonoids,and possessed a wide range of biological activities,such as anti-inflammatory,analgesic,hepatoprotective,antitumor,regulating gastrointestinal function and regulating nervous system,etc.It is widely used for herpes zoster,hypertension,sudden deafness and various inflammatory diseases in clinic.The chemical constituents,biological activities and clinical applications of Gentianae Radix et Rhizoma were reviewed to provide theoretical reference and scientific basis for further development and utilization.