胆汁酸影响乙肝疫苗免疫应答的研究进展

Research Progress on the Influence of Bile Acids on the Immune Response of Hepatitis B Vaccine

接种乙型肝炎疫苗(HepB)是预防乙型肝炎病毒(HBV)感染最安全、有效的手段。HepB无应答受多种因素影响,解决接种HepB后的免疫应答不良问题对控制HBV感染具有重要意义。胆汁酸对人体免疫调节发挥重要作用,胆汁酸是否对HepB免疫应答产生影响,目前尚无确切研究。本文就胆汁酸与HepB免疫应答之间相关性进行综述,为进一步明确胆汁酸在疫苗免疫的发病机制及免疫预防提供参考。

Hepatitis B vaccine(HepB)vaccination is the safest and most effective means of preventing hepatitis B vi⁃rus(HBV)infection.HepB non-response is influenced by multiple factors,and solving the problem of poor immune re⁃sponse after HepB vaccination is of great significance for controlling HBV infection.Bile acids play an important role in hu⁃man immune regulation,and whether bile acids have an effect on the HepB immune response has not been definitively studied.This article reviews the correlation between bile acids and HepB immune response,and provides a reference for further clarifying the pathogenesis and immunoprevention of bile acids in vaccine immunity.