炎症相关因子和长链非编码RNA与缺血性脑卒中的相关性研究

Study on the association of ischemic stroke with inflammation-related factors and long non-coding RNA

缺血性脑卒中是一种涉及脑血供受损的急性疾病,其特点是高发病率、病死率、复发率和残疾率,严重影响着患者的心理和生理,并且可降低患者的生活质量,给其家庭和社会带来了沉重的经济负担。因此,入院时的早期诊断和迅速恢复缺血部位正常血流是决定缺血性脑卒中患者病程的关键因素。本综述讨论了炎症相关因子及长链非编码RNA在缺血性脑卒中的作用机制,有望采用更综合、更全面的方法来识别早期和中期临床脑损伤标志物,对于预测、支持性管理策略、病情诊断以及未来有针对性的预防和管理策略的改进至关重要。

Ischemic stroke is a kind of acute disease involving cerebral blood supply damage,which is characterized by high incidence,death,death rate,recurrence rate and disability rate,seriously affect the psychological and physiological of patients,and can reduce the quality of life of patients,to its family and society has brought serious economic burden.Therefore,early diagnosis on admission and rapid restoration of normal blood flow at the ischemic site are the key factors to determine the course of ischemic stroke patients.This review discusses the mechanisms of action of a number of inflammatory factors and long non-coding RNA in ischemic stroke,promising a more integrated and comprehensive approach to identify early and mid-stage clinical markers of brain injury,which will be essential for prediction,supportive management strategies,diagnosis of the condition,and future improvements in targeted prevention and management strategies.