六味地黄丸对骨质疏松性椎体骨折患者血清骨特异性碱性磷酸酶、抗酒石酸酸性磷酸酶-5b及骨密度的影响

Effect of Liuwei Dihuang Pills on serum bone alkaline phosphatase,tartrate resistant acid phosphatase-5b and bone mineral density in patients with osteoporotic vertebral fracture

目的探讨骨质疏松性椎体骨折患者采用六味地黄丸治疗的效果。方法选取2021年2月至2022年2月衡阳市中医医院收治的80例骨质疏松性椎体骨折患者作为研究对象,采用随机数字表法将其分为对照组(40例)和观察组(40例)。对照组采用手术联合西药治疗,观察组加用六味地黄丸治疗。比较两组的骨密度、血清骨碱性磷酸酶(BALP)、抗酒石酸酸性磷酸酶5b(TRACP-5b)、Oswestry功能障碍指数(ODI)评分。结果观察组治疗后的骨密度水平高于对照组,差异有统计学意义(P<0.05);两组治疗前的血清BALP、TRACP-5b水平的比较,差异无统计学意义(P>0.05),观察组治疗后血清BALP、TRACP-5b水平低于对照组,差异有统计学意义(P<0.05),两组治疗前ODI评分比较,差异无统计学意义(P>0.05),观察组治疗后的ODI评分低于对照组,差异有统计学意义(P<0.05)。结论六味地黄丸治疗骨质疏松性椎体骨折的效果明显,患者骨密度明显升高,其机体血清指标下降,患者功能障碍改善明显,临床上可借鉴及推广。

Objective To investigate the effect of Liuwei Dihuang Pills in the treatment of osteoporotic vertebral fracture.Methods A total of 80 patients with osteoporotic vertebral fracture hospitalized in Hengyang Hospital of Traditional Chinese Medicine from February 2021 to February 2022 were selected as the study objects,and were divided into control group(40 cases)and observation group(40 cases)by random number table method.The control group was treated with operation combined with western medicine,the observation group was treated with Liuwei Dihuang Pills.The bone density index,serum bone alkaline phosphatase(BALP),tartrate resistant acid phosphatase-5b(TRACP-5b)and Oswestry disability index(ODI)scores of the two groups were compared.Results The bone density index level of observation group was higher than that of control group after treatment,and the difference was statistically significant(P<0.05).There was no statistical significance in serum BALP and TRACP-5b levels between the two groups before treatment(P>0.05),serum BALP and TRACP-5b levels in the observation group after treatment were lower than those in the control group,with statistical significance(P<0.05).There was no statistical significance in ODI scores between the two groups before treatment(P>0.05).The ODI score of the observation group was lower than that of the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion Liuwei Dihuang Pills has obvious effect on the treatment of osteoporotic vertebral fracture,the bone mineral density of patients is obviously increased,the serum index of patients is decreased,and the dysfunction of patients is obviously improved,which can be used for reference and promotion in clinic.