康复新液治疗胃溃疡的临床疗效及对炎性因子、氧化应激和胃黏膜修复作用的影响分析

Clinical Efficacy of KangfuxinLiquid on Gastric Ulcer and Its Effect on Inflammatory Factors,Oxidative Stress and Gastric Mucosal Repair

目的探讨康复新液治疗胃溃疡的临床疗效,分析其对炎性因子、氧化应激和胃黏膜修复作用的影响。方法选取2018年1月至2022年10月于九江市柴桑区人民医院住院的胃溃疡患者90例,依据随机数字法分为对照组和观察组各45例。对照组给予常规治疗,观察组在对照组基础上加用康复新。观察两组患者的临床疗效以及对炎性因子、氧化应激和胃黏膜修复作用的影响。结果观察组有效率为97.78%,高于对照组的84.44%,根治率为97.78%,高于对照组的86.67%,复发率为4.44%,低于对照组的17.78%,差异有统计学意义(P<0.05)。观察组腹痛、腹胀、恶心、反酸、嗳气症状改善时间明显优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-a(Tumor necrosis factor-a,TNF-a)、C反应蛋白(C-reactive protein,CRP)、丙二醛(Malondialdehyde,MDA)、血清内皮素-1(Serum endothelin,ET-1)、基础胃酸分泌量(Basic gastric acid secretion,BAO)、高峰胃酸分泌量(Peak gastric acid secretion,PAO)、最大胃酸分泌量(Maximum gastric acid secretion,MAO)水平较前降低,超氧化物歧化酶(Superoxide dismutase,SOD)、表皮生长因子(Epidermal Growth Factor,EGF)水平较治疗前升高,且观察组上述指标均优于对照组,差异有统计学意义(P<0.05)。结论康复新液治疗胃溃疡的临床疗效显著,降低炎症反应和氧化应激水平,促进胃黏膜的修复,愈合时间短,复发率低,值得临床推广。

Objectives Toinvestigate the clinical efficacy of KangfuxinLiquid in the treatment of gastric ulcer,and to analyze its effect on inflammatory factors,oxidative stress and gastric mucosal repair.Methods A total of 90 patients with gastric ulcer hospitalized inChaisang District People's Hospital in Jiujiang City from January 2018 to October 2022 were selected and randomly divided into control group and observation group,with 45 patients in each group.The control group was given routine treatment,and the observation group was treated withKangfuxin on the basis of the control group.The clinical efficacy in the two groups and treatment effect on inflammatory factors,oxidative stress and gastric mucosal repair were observed.Results Theeffective rate of the observation group was 97.78%,which was significantly higher than the 84.44%of the control group.The radical cure rate of the observation group was 97.78%,which was significantly higher than the 86.67%of the control group.The recurrence rate of the observation group was 4.44%,which was significantly lower than the 17.78%of the control group(P<0.05).The improvement time of abdominal pain,abdominal distension,nausea,acid reflux,and belching symptoms in the observation group was significantly better than that in the control group(P<0.05).After treatment,the levels of Interleukin-6(IL-6),Interleukin-8(IL-8),Tumor necrosis factor-a(TNF-a),C-reactive protein(CRP),Malondialdehyde(MDA),Serum endothelin-1(ET-1),Basic gastric acid secretion(BAO),Peak gastric acid secretion(PAO)and Maximum gastric acid secretion(MAO)in the two groups were significantly lower than those before treatment.The levels of superoxide dismutase(SOD)and Epidermal growth factor(EGF)were significantly higher than those before treatment.The above indexes in the observation group were superior to the control group,and the difference was statistically significant(P<0.05).Conclusions KangfuxinLiquid has a significant clinical effect in treating gastric ulcer,reducing the level of inflammatory reaction and oxidative stress,promoting the repair of gastric mucosa,with short healing time and low recurrence rate,which is worthy of clinical promotion.