摘要
Hippo信号通路下游效应器蛋白Yes相关蛋白(YAP)和转录辅助激活因子(TAZ)的异常激活参与肝细胞癌(HCC)恶性进展。微小RNA(miRNAs)作为抑癌基因通过Hippo YAP/TAZ信号影响HCC增殖、迁移和凋亡等途径调控HCC恶性生物学表型。探索miRNAs调节Hippo YAP/TAZ通路在HCC中的作用可为诊断和治疗HCC提供新的思路。
The aberrant activation of yes-associated protein(YAP)and transcriptional coactivator with PDZ-binding motif(TAZ),downstream effectors of the Hippo signaling pathway,has been implicated in hepatocellular carcinoma(HCC).The microRNAs(miRNAs)works as a tumor suppressors that influence the proliferation,migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis.Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diagnosis and treatment of HCC.
作者
查娜
郝丹丹
李天柱
CHA Na;HAO Dandan;LI Tianzhu(Department of Oncology,the Affiliated Hospital of Chifeng University,Chifeng 024000;Department of Physiology,School of Basic Medical Science,Chifeng University,Chifeng 024000,China;Molecular Medicine Research Center,School of Basic Medical Science,Chifeng University,Chifeng 024000,China)
出处
《基础医学与临床》
2023年第12期1871-1875,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(82060118)
内蒙古自治区高等学校科学研究项目(NJZY20203)
赤峰学院青年科技英才项目(CFXYYT2202)
内蒙古自然科学基金(2022MS08032)。
