阿仑磷酸钠辅助PVP治疗对老年骨质疏松性压缩性骨折BALP、PTH及N-MID-OT水平的影响

Effects of alendronate sodium adjuvant PVP therapy on BALP,PTH and N-MID-OT levels in elderly patients with osteoporotic compression fractures

目的分析阿仑磷酸钠辅助经皮椎体成形术(PVP)治疗对老年骨质疏松性压缩性骨折骨碱性磷酸酶(BALP)、甲状旁腺激素(PTH)及N端中段骨钙素(N-MID-OT)水平的影响。方法选取2019年1月至2022年2月唐山市丰润区人民医院收治的老年骨质疏松性压缩性骨折患者107例,按照治疗方式不同分为观察组和对照组,对照组采取PVP治疗(n=52),观察组采取阿仑磷酸钠辅助PVP治疗(n=55)。对比两组Oswestry功能障碍指数问卷表(ODI)、视觉模拟量表(VAS)、骨代谢指标(BALP、PTH、N-MID-OT水平)、不良反应及再骨折发生率。结果两组术后2个月、6个月、12个月ODI评分均下降,且观察组术后各时间段ODI评分均低于对照组,差异有统计学意义(P<0.05)。两组术后2个月、6个月、12个月VAS评分均下降,且观察组术后各时间段VAS评分均低于对照组,差异有统计学意义(P<0.05)。两组术后BALP、PTH及N-MID-OT水平均下降,且观察组术后BALP、PTH及N-MID-OT水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05),但观察组再骨折发生率(7.28%)明显低于对照组(25.00%),差异有统计学意义(P<0.05)。结论阿仑磷酸钠辅助PVP治疗可有效改善老年骨质疏松性压缩性骨折患者椎体功能,减轻其疼痛程度,改善患者体内BALP、PTH及N-MID-OT水平,促进其术后恢复。

Objective To analyze the effects of alendronate-assisted percutaneous vertebroplasty(PVP)in the treatment of osteoporotic compression fractures in elderly patients on bone alkaline phasphatase(BALP),parathyroid hormone(PTH)and N-end middle Osteocalcin(N-MID-OT)levels.Methods 107 elderly patients with osteoporotic compression fracture treated in Fenggrun District People's Hospital of Tangshan City from January 2019 to February 2022 were selected and divided into an observation group and a con-trol group according to different treatment methods,the control group was treated with PVP(n=52),the observation group took alendronate sodium as auxiliary PVP treatment(n=55).The Oswestry Disability Index questionnaire(ODI),visual analogue scale(VAS),bone metabolism indicators(BALP,PTH,N-MID-OT levels),adverse reactions and the incidence of refracture between the two groups were compared.Results The ODI scores of both groups decreased at 2 months,6 months,and 12 months after operation,and the ODI scores of the observation group were lower than those of the control group at all time periods after surgery,the difference was statistically significant(P<0.05).The VAS scores of both groups decreased at 2 months,6 months,and 12 months after surgery,and the VAS scores of the observation group were lower than those of the control group at all time periods after surgery,the difference was statistically significant(P<0.05).The levels of BALP,PTH and N-MID-OT in both groups decreased after operation,and the levels of BALP,PTH and N-MIDOT in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Comparing the total incidence of adverse reactions between the two groups,the difference was not statistically significant,the difference was statistically significant(P>0.05),but the incidence of re-fracture in the observation group(7.28%)was significantly lower than that in the control group(25.00%),the difference was statistically significant(P<0.05).Conclusion Alendronate sodium adjuvant PVP therapy can effectively improve the vertebral function of elderly patients with osteoporotic compression fractures,reduce their pain,improve the levels of BALP,PTH and N-MID-OT in patients,and promote their postoperative recovery.