78例小儿急性上呼吸道感染的临床诊治分析

Clinical diagnosis and treatment of 78 cases of acute upper respiratory tract infection in children

目的分析小儿急性上呼吸道感染的临床诊治方法与效果。方法回顾性分析78例小儿急性上呼吸道感染患儿的临床资料,根据治疗方式的差异分成参照组与实验组,每组39例。参照组采取常规治疗,实验组采取常规联合蒲地蓝治疗。比较两组的治疗效果、临床症状消失时间、治疗前后的炎性因子[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-10]水平。结果治疗后,实验组治疗总有效率100.00%明显高于参照组的84.62%,差异具备统计学意义(P<0.05)。实验组咽喉肿痛、发烧、咳嗽、流鼻涕消失时间分别为(2.62±0.55)、(1.52±0.72)、(2.56±0.58)、(2.23±0.48)d,明显短于参照组的(3.85±1.25)、(2.36±1.01)、(4.22±1.25)、(4.11±1.35)d,差异具备统计学意义(P<0.05)。治疗前,两组CRP、TNF-α、IL-1β、IL-10水平比较无差异(P>0.05);治疗后,实验组CRP(3.53±0.11)mg/L、TNF-α(4.80±1.31)ng/L、IL-1β(22.16±12.06)ng/L、IL-10(74.76±6.76)ng/L均低于参照组的(8.96±2.56)mg/L、(7.76±1.65)ng/L、(55.16±23.64)ng/L、(65.86±8.46)ng/L,差异具备统计学意义(P<0.05)。结论对小儿急性上呼吸道感染开展常规和蒲地蓝联合治疗效果显著,可明显缩短患儿机体康复的时间,促进炎症因子降低,值得推荐。

Objective To analyze the clinical diagnosis and treatment methods and effects of acute upper respiratory tract infection in children.Methods The clinical data of 78 children with acute upper respiratory tract infection were retrospectively analyzed.According to the differences in treatment methods,they were divided into a reference group and an experimental group,with 39 cases in each group.The reference group received routine treatment,while the experimental group received routine treatment combined with Pu Di Lan treatment.Both groups were compared in terms of therapeutic effect,clinical symptom disappearance time,and inflammatory factors[C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-10]level before and after treatment.Results After treatment,the total therapeutic effect of 100.00%in the experimental group was significantly higher than that of 84.26%in the reference group,with statistical significance(P<0.05).The disappearance time of sore throat,fever,cough,and runny nose in the experimental group were(2.62±0.55),(1.52±0.72),(2.56±0.58)and(2.23±0.48)d,which were significantly shorter than(3.85±1.25),(2.36±1.01),(4.22±1.25)and(4.11±1.35)d in the reference group,with statistical significance(P<0.05).Before treatment,there was no difference in levels of CRP,TNF-α,IL-1βand IL-10 between the two groups(P>0.05).After treatment,the experimental group had CRP of(3.53±0.11)mg/L,TNF-αof(4.80±1.31)ng/L,IL-1βof(22.16±12.06)ng/L and IL-10 of(74.76±6.76)ng/L,which were lower than(8.96±2.56)mg/L,(7.76±1.65)ng/L,(55.16±23.64)ng/L and(65.86±8.46)ng/L in the reference group,with statistical significance(P<0.05).Conclusion For acute upper respiratory tract infections in children,routine treatment and Pu Di Lan treatment havesignificant effect,which can obviously shorten the recovery time of the body and promote the reduction of inflammatory factors,which is worth recommending.