四种肠胃药品的太赫兹光谱实验分析

Terahertz Spectroscopy Experimental Analysis of FourGastrointestinal Drugs

利用太赫兹时域光谱(THz-TDS)技术,测量并分析了肠炎宁胶囊、枸橼酸铋钾胶囊、雷贝拉唑钠肠溶片和双歧杆菌三联活菌胶囊4种肠胃类药品在0.25~2.40 THz波段内的光谱特性。实验结果发现4种药品光谱并不存在关联,因此THz-TDS技术不能进行药品成分鉴别和药效归类;太赫兹波对微弱的结构变化敏感,对含有相同辅料的药品依然可以精确鉴定;对比失效药品的光谱特性存在明显差异,表现为吸收峰位的移动、新增和消失等。该实验研究为使用THz-TDS技术进行药品鉴别及药效鉴定提供参考。

Terahertz time-domain spectroscopy(THz-TDS)is used to quantify and analyze the spectral characteristics of four gastrointestinal drugs:Enteritis capsules,Bismuth Citrate Potassium capsules,Rabeprazole Sodium enteric tablets,and Bifidobacterium Triptans capsules in the 0.25‒2.40 THz band.Terahertz waves are sensitive to weak structural changes and can accurately identify drugs containing the same excipients.The experimental results show that the spectra of the four drugs are distinctly different;thus,THz-TDS technology cannot be used to identify drug components and classify drug effects.Additionally,there are evident differences in the spectral characteristics compared with those of the failed drugs manifested by the shift,addition,and disappearance of absorption peaks.The experimental study provides reference data for drug identification and efficacy identification by THz-TDS.