脑脊液抗GFAP抗体阳性的原发性中枢神经系统淋巴瘤1例报告

Primary central nervous system lymphoma with positive anti-GFAP antibody in cerebrospinal fluid:a case re‑port

本文报道1例原发性中枢神经系统淋巴瘤(PCNSL)病例。患者为青年男性,亚急性起病,病情迁延8月余,主要表现为逐渐加重的头痛及头晕,头部核磁影像提示脑室扩张、脑积水,脑膜强化;早期脱水降颅压后头痛症状可缓解;脑脊液中抗GFAP抗体阳性,经激素治疗后症状一度好转,然而激素减量后头痛症状再次加重;最终经脑脊液细胞学、脑脊液免疫细胞化学染色得以明确诊断PCNSL。

This article reports a case of primary central nervous system lymphoma(PCNSL).The patient was a young man with subacute onset,and the disease lasted for more than 8 months and had the main manifestations of gradu‑ally aggravated headache and dizziness.Cranial MRI showed ventricular dilatation,hydrocephalus,and meningeal en‑hancement.Dehydration treatment aiming to reduce intracranial pressure alleviated the symptom of headache in the early stage of the disease;the cerebrospinal fluid was tested positive for anti-GFAP antibodies,and the symptoms were im‑proved temporarily after hormone treatment.However,the symptom of headache aggravated again after hormone reduc‑tion.Finally,the patient was diagnosed with PCNSL based on cerebrospinal fluid cytology and cerebrospinal fluid immuno‑cytochemistry staining.