去泛素化酶在肾细胞癌中的作用

The Roles of Deubiquitinases in Renal Cell Carcinoma

肾细胞癌(renal cell carcinoma,RCC)是成人肾脏的原发性恶性肿瘤。泛素-蛋白酶体系统(ubiquitinproteasome system,UPS)对控制蛋白质水平和调节生理病理过程至关重要。去泛素化酶(deubiquitinases,DUBs)是UPS的关键成分,特别是从靶蛋白中去除泛素链,通过严格调节正常生理学中泛素化和去泛素化之间的平衡,对蛋白质稳态和质量控制显示出至关重要的作用。越来越多的研究表明,功能异常的DUBs与RCC的进展和转移有关。根据底物的不同,一些DUB可能会抑制RCC,而另一些则促进。本文综述了RCC相关DUB的最新研究进展,描述了其分类、功能作用,总结了DUB在RCC中的作用和作用机制,并讨论了靶向DUBs用于癌症治疗。

Renal cell carcinoma(RCC)is the primary malignant neoplasm.The ubiquitin-proteasome system(UPS)is crucial to the control of protein level and regulation of physiological and pathological processes.Deubiquitinases(DUBs),key components of UPS,specifically removing ubiquitin chains from the target protein,have showed crucial roles for protein homeostasis and quality control by rigidly regulating the balance between ubiquitination and deubiquitination in normal physiology.Accumulating studies indicate that abnormal function DUBs is associated with the progression and metastasis of RCC.Depending on the substrates,some DUBs may suppress RCC while others promote.Herein,we review recent research advances in RCC-associated DUBs,describe their classification,functional roles,summarize the role and mechanisms of action of DUBs in RCC and discuss the potential of targeting DUBs for cancer treatment.