祛湿生发汤联合点阵激光、米诺地尔治疗湿热型雄激素源性脱发的效果及对TGF-β_(1)、VEGF水平的影响

Effect of Qushi Shengfa decoction combined with fractional laser and minoxidil in the treatment of damp-heat androgenetic alopecia and its influences on TGF-β_(1) and VEGF levels

目的分析祛湿生发汤联合点阵激光、米诺地尔治疗湿热型雄激素源性脱发的效果及对转化生长因子-β_(1)(TGF-β_(1))、血管内皮生长因子(VEGF)水平的影响。方法选择2019年2月至2022年3月收治的80例湿热型雄激素源性脱发患者进行研究,以随机数字表法将其分为对照组、观察组,每组40例。对照组接受点阵激光、米诺地尔治疗,观察组在对照组治疗方案基础上加用祛湿生发汤。比较两组的治疗效果。结果治疗后,观察组的平均毳毛比例、单根毛发毛囊比例低于对照组,毛发密度大于对照组(P<0.05)。治疗后,观察组的TGF-β_(1)水平低于对照组,VEGF水平高于对照组(P<0.05)。治疗后,观察组的全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PV)、红细胞聚集指数(Arbc)均低于对照组(P<0.05)。结论祛湿生发汤联合点阵激光、米诺地尔治疗湿热型雄激素源性脱发可调节TGF-β_(1)、VEGF水平,改善血液流变学指标,促进毛发状态恢复,值得推广。

Objective To analyze the effect of Qushi Shengfa decoction combined with fractional laser and minoxidil in the treatment of damp-heat androgenetic alopecia and its influences on transforming growth factor-β_(1)(TGF-β_(1))and vascular endothelial growth factor(VEGF)levels.Methods A total of 80 patients with damp-heat androgenic alopecia treated from February 2019 to March 2022 were selected for this study.The patients were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with fractional laser and minoxidil,and the observation group was treated with Qushi Shengfa decoction on the basis of the treatment plan of the control group.The treatment effects of the two groups were compared.Results After treatment,the average vellus hair proportion and single hair follicle proportion of the observation group were lower than those of the control group,and the hair density was higher than that of the control group(P<0.05).After treatment,the level of TGF-β_(1) in the observation group was lower than that in the control group,and the level of VEGF was higher than that in the control group(P<0.05).After treatment,high blood viscosity(HBV),low blood viscosity(LBV),plasma viscosity(PV)and red blood ceel assembling index(Arbc)in the observation group were lower than those in the control group(P<0.05).Conclusion Qushi Shengfa decoction combined with fractional laser and minoxidil in the treatment of damp-heat androgenic alopecia can regulate the levels of TGF-β_(1) and VEGF,improve hemorheological indexes,and promote the recovery of hair state,which is worthy of promotion.