四金石灵膏联合帕瑞昔布治疗湿热瘀阻型输尿管结石伴肾绞痛的效果研究

Study on effect of Sijinshiling ointment combined with parecoxib in the treatment of ureteral calculi with renal colic of damp heat stasis type

目的分析四金石灵膏联合帕瑞昔布治疗湿热瘀阻型输尿管结石伴肾绞痛的临床效果。方法116例湿热瘀阻型输尿管结石伴肾绞痛患者,按随机数字表法分为对照组及观察组,每组58例。对照组采用注射用帕瑞昔布钠治疗,观察组采用注射用帕瑞昔布钠联合四金石灵膏治疗。比较两组治疗前后的中医证候积分、视觉模拟评分法(VAS)评分及24 h尿生化指标[尿酸(UA)、尿草酸(UOA)、尿钙(U-Ca)],不良反应发生情况,疗效。结果治疗后,两组腰腹疼痛、小便艰涩、口干欲饮、大便干结中医证候积分均下降,且观察组腰腹疼痛、小便艰涩、口干欲饮、大便干结中医证候积分分别为(0.20±0.05)、(0.27±0.04)、(0.34±0.04)、(0.34±0.04)分,均低于对照组的(0.77±0.11)、(0.91±0.08)、(0.89±0.21)、(0.38±0.05)分,有统计学差异(P<0.05)。治疗后,两组VAS评分下降,且观察组VAS评分(1.22±0.23)分低于对照组的(3.21±0.67)分,有统计学差异(P<0.05)。治疗后,两组24 h尿生化指标UA、U-Ca、UOA均下降,且观察组24 h尿生化指标UA、U-Ca、UOA分别为(2.80±0.95)、(3.27±1.32)、(0.22±0.08)mmol/d,均低于对照组的(3.63±1.03)、(4.64±0.19)、(0.39±0.14)mmol/d,有统计学差异(P<0.05)。治疗后,观察组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。观察组总有效率96.55%高于对照组的82.76%,有统计学差异(P<0.05)。结论四金石灵膏联合帕瑞昔布治疗湿热瘀阻型输尿管结石伴肾绞痛患者,可快速缓解疼痛,利于结石排出体外,改善其生命健康质量,值得推广。

Objective To analyze the clinical effect of Sijinshiling ointment combined with parecoxib in the treatment of ureteral calculi with renal colic of damp heat stasis type.Methods 116 cases of ureteral calculi with renal colic of damp heat stasis type were divided into a control group and an observation group according to random number table,with 58 patients in each group.The control group was treated with parecoxib sodium for injection,while the observation group was treated with parecoxib sodium for injection combined with Sijinshiling ointment.Both groups were compared in terms of traditional Chinese medicine syndrome scores,visual analogue scale(VAS)score,and 24-h urine biochemical indicators[uric acid(UA),urinary oxalic acid(UOA),urinary calcium(U-Ca)]before and after treatment,and adverse reactions.Results After treatment,the traditional Chinese medicine syndrome scores of lumbar and abdominal pain,difficult urination,dry mouth and thirst,and dry stool in both groups significantly decreased;the traditional Chinese medicine syndrome scores oflumbar and abdominal pain,difficult urination,dry mouth and thirst,and dry stool were(0.20±0.05),(0.27±0.04),(0.34±0.04)and(0.34±0.04)points,which were lower than(0.77±0.11),(0.91±0.08),(0.89±0.21)and(0.38±0.05)points in the control group;there was statistical difference(P<0.05).After treatment,the VAS score in both groups decreased,and the VAS score of(1.22±0.23)points in the observation group was lower than(3.21±0.67)points in the control group,and there was statistical difference(P<0.05).After treatment,the 24 h urinary biochemical indexes of UA,U-Ca and UOA decreased in both groups.The 24-h urine biochemical indicators of UA,U-Ca and UOA in the observation group were(2.80±0.95),(3.27±1.32)and(0.22±0.08)mmol/d,which were lower than(3.63±1.03),(4.64±0.19)and(0.39±0.14)mmol/d in the control group.There was statistical difference(P<0.05).After treatment,the incidence of adverse reactions in the observation group was lower than that in the control group,but the difference was not statistically significant(P>0.05).The total effective rate of 96.55%in the observation group was higher than 82.76%in the control group,and there was statistical difference(P<0.05).Conclusion Sijinshiling ointment combined with parecoxib in the treatment of ureteral calculi with renal colic of damp heat stasis type can quickly relieve the pain,facilitate the excretion of stones,and improve their quality of life and health,which is worth popularizing.