甲泼尼龙琥珀酸钠联合孟鲁司特钠治疗小儿过敏性紫癜的效果及对症状消失时间和炎症因子的影响

Effect of Methylprednisolone Sodium Succinate combined with Montelukast Sodium in the treatment of children with allergic purpura and its influence on symptom disappearance time and inflammatory factors

目的探讨甲泼尼龙琥珀酸钠联合孟鲁司特钠治疗小儿过敏性紫癜的效果及对症状消失时间和炎症因子的影响。方法选取莒县人民医院2020年1月至2023年2月收治的76例过敏性紫癜患儿作为研究对象,采用随机数字表法分为对照组和研究组,每组各38例。对照组采用甲泼尼龙琥珀酸钠治疗,研究组在对照组的基础上联合孟鲁司特钠治疗。比较两组炎症因子水平、症状消失时间及治疗安全性。结果研究组C反应蛋白、白细胞介素-6和肿瘤坏死因子-α水平均低于对照组(P<0.05);研究组各项症状消失时间均短于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论甲泼尼龙琥珀酸钠联合孟鲁司特钠治疗小儿过敏性紫癜可减轻炎症反应,缓解临床症状,值得临床应用。

Objective To explore the effect of Methylprednisolone Sodium Succinate combined with Montelukast Sodium in the treatment of children with allergic purpura and its influence on symptom disappearance time and inflammatory factors.Methods A total of 76 children with allergic purpura admitted to Juxian People’s Hospital from January 2020 to February 2023 were selected as the study objects.All the children were divided into the control group and the study group by the random number table method,with 38 cases in each group.The control group was treated with Methylprednisolone Sodium Succinate,and the observation group was treated with Montelukast Sodium on the basis of the control group.The levels of inflammatory factors,symptom disappearance time and treatment safety were compared between the two groups.Results The levels of C-reactive protein,interleukin-6 and tumor necrosis factor-αin the study group were lower than those in the control group(P<0.05).The disappearance time of various symptoms in the study group was shorter than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion Methylprednisolone Sodium Succinate combined with Montelukast Sodium in the treatment of children with allergic purpura can reduce inflammatory reaction and relieve clinical symptoms,which is worthy of clinical application.