干细胞治疗类风湿性关节炎的研究进展

Research progress of stem cell therapy for rheumatoid arthritis

目的类风湿性关节炎(rheumatoid arthritis,RA)是一种发病机制复杂的免疫性疾病,近年来干细胞因其强大的免疫调节和抗炎能力成为治疗免疫性疾病的研究热点,本文作者综述了干细胞疗法在RA治疗中的研究进展,为后续研究作参考。方法通过Pubmed和知网等平台,检索国内外相关文献,对干细胞疗法对RA的治疗进展进行总结分析。结果干细胞通过“免疫重置”或抑制自身免疫有效对抗RA,目前间充质干细胞和造血干细胞移植治疗可明显改善RA患者的临床症状,降低类风湿因子(rheumatoid factor,RF)、抗环瓜氨酸肽抗体(抗CCP抗体)以及C反应蛋白(C-reactive protein,CRP)等指标,减轻疾病活动度,治疗过程安全可行且无明显的不良反应。结论干细胞疗法安全有效,但仍存在一些局限性,今后可通过大量临床试验进一步探究,为RA患者带来更大的获益。

Objective Rheumatoid arthritis(RA)is an immune disease with complex pathogenesis.Recently,stem cell have become a research hotspot in the treatment of immune diseases because of their strong immune regulation and anti-inflammatory ability.This article reviews the research progress of stem cell therapy in the treatment of RA,which can be used as a reference for follow-up research.Methods The progress of stem cell therapy in the treatment of RA was summarized and analyzed by searching the relevant literatures at home and abroad through the platforms of Pubmed and CNKI.Results Stem cells can effectively resist RA by“immune reset”or suppression of autoimmunity.At present,mesenchymal stem cell and hematopoietic stem cell transplantation can significantly improve the clinical symptoms of RA patients,reduce rheumatoid factor,anti-cyclic citrullinated peptide antibody and C-reactive protein,and reduce disease activity.The treatment process is safe and feasible with no obvious adverse reactions.Conclusion Stem cell therapy is safe and effective,but there are still some limitations,which can be further explored through a large number of clinical trials in the future to bring greater benefits to RA patients.