Lp-PLA2和SAA与急性脑梗死患者颈动脉内中膜厚度的相关性研究

Correlation between Lp-PLA2 and SAA and Carotid Intima-media Thickness in Patients with Acute Cerebral Infarction

目的探究脂蛋白相关磷脂酶A2(Lipoprotein-associated Phospholipase A2,Lp-PLA2)和血清淀粉样蛋白A(Serum Amyloidprotein A,SAA)与急性脑梗死患者颈动脉内中膜厚度的相关性。方法选择2022年1—12月于揭阳市神经内科住院治疗的100例急性脑梗死患者作为病例组,选择100例同期体检健康者作为对照组。对比病例组和对照组Lp-PLA2、SAA水平,比较不同颈动脉内中膜厚度患者的Lp-PLA2、SAA水平并进行相关性分析。结果病例组的Lp-PLA2、SAA水平高于对照组,差异有统计学意义(P均<0.05);内膜正常组LpPLA2水平(248.41±25.46)μg/L、内膜增厚组(278.38±27.31)μg/L及斑块形成组(302.15±30.80)μg/L依次升高;内膜正常组SAA水平(52.12±15.46)mg/L、内膜增厚组(68.46±18.49)mg/L及斑块形成组(76.24±19.31)mg/L依次升高,差异有统计学意义(F=3.542、3.165,P均<0.05);相关性分析结果显示Lp-PLA2和SAA与急性脑梗死患者颈动脉内中膜厚度的相关性呈正相关(P均<0.05)。结论Lp-PLA2和SAA与急性脑梗死患者颈动脉内中膜厚度具有正相关,因此需根据患者Lp-PLA2和SAA水平对其进行及时的治疗,以防止疾病恶化。

Objective To explore the correlation between lipoprotein-associated phospholipase A2(Lp-PLA2)and se⁃rum amyloid protein A(SAA)and carotid intima-media thickness in patients with acute cerebral infarction.Methods A total of 100 patients with acute cerebral infarction who were hospitalized in the Department of Neurology of Jieyang City from January 2022 to December 2022 were selected as the case group and 100 healthy subjects during the same period were selected as the control group.The levels of Lp-PLA2 and SAA were compared between the case group and the control group,and the levels of Lp-PLA2 and SAA in patients with different carotid intima-media thickness were compared and the correlation analysis was performed.Results The levels of Lp-PLA2 and SAA in case group were higher than those in control group,and the differences were statistically significant(both P<0.05).The levels of Lp-PLA2 in normal intima group(248.41±25.46)μg/L,thickening intima group(278.38±27.31)μg/L and plaque for⁃mation group(302.15±30.80)μg/L were increased successively;the levels of SAA in normal intima group(52.12±15.46)mg/L,thickening intima group(68.46±18.49)mg/L and plaque formation group(76.24±19.31)mg/L were in⁃creased successively,and the differences were statistically significant(F=3.542,3.165,both P<0.05).Correlation analysis showed that Lp-PLA2 and SAA were positively correlated with carotid intima-media thickness in patients with acute cerebral infarction(both P<0.05).Conclusion Lp-PLA2 and SAA are positively correlated with carotid intima-media thickness in patients with acute cerebral infarction,so it is necessary to timely treat Lp-PLA2 and SAA levels in patients to prevent disease deterioration.