抗抑郁药物不良反应及其对治疗依从性的影响研究

Research of Adverse Reactions of Antidepressants and Effect on Treatment Compliance

目的探讨抗抑郁药物不良反应及其对治疗依从性的影响。方法选取2021年3月—2022年12月建湖县第三人民医院收治的60例抑郁症患者作为研究对象,根据随机对照表分为两组,其中观察组30例,对照组30例。对照组接受常规抗抑郁药物治疗,观察组在常规抗抑郁药物基础上加用舒肝解郁胶囊治疗,比较两组患者治疗后抑郁症程度(HAMD评分)、不良反应以及治疗依从性(MARS量表)。结果治疗后,观察组HAMD评分优于对照组(P<0.05);观察组治疗后药物不良反应发生率低于对照组(P<0.05);观察者治疗依从性高于对照组(P<0.05)。结论减少抑郁症患者用药后的不良反应发生率可以有效提高患者依从性,提升患者生活质量。

Objective To explore adverse reactions of antidepressants and effect on treatment compliance.Methods The paper chose 60 patients with depression admitted to Jianhu County the Third People's Hospital from March 2021 to December 2022 as study subjects,and divided them into two groups according to randomized control table,with 30 cases in observation group and 30 cases in control group.Control group was treated with routine antidepressant medication treatment,while observation group with soothing liver-qi stagnation capsules in addition to routine antidepressant medication.Degree of depression(HAMD scores),adverse reactions,and treatment compliance(MARS scale)was compared between two groups after treatment.Results After treatment,HAMD scores of observation group were higher than control group(P<0.05).Incidence of adverse drug reactions after treatment in observation group was lower than control group(P<0.05).treatment compliance in observation group was higher than control group(P<0.05).Conclusion Reducing incidence of adverse reactions of depression patients after medication can improve compliance and enhance life quality of patients effectively.