寻常痤疮再认识:从发病机制到治疗策略

Acne vulgaris revisited:from pathogenesis to treatment strategies

寻常痤疮是毛囊皮脂腺单位慢性炎症性疾病,其发病机制与雄激素诱导的脂质大量分泌、毛囊皮脂腺导管角化异常、毛囊微生物增殖及炎症和免疫反应密切相关,但具体的发病机制和病理生理过程仍未完全揭示。近年来随着研究不断深入,传统认知也不断更新并影响着临床治疗理念的转变。本文从激素水平、毛囊微生物、毛囊皮脂腺干细胞分化及重度痤疮发生机制等角度总结寻常痤疮发生机制中部分新观点、新理念及其在临床防治中的意义,为痤疮防治提供新的方向和思路。

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit.Androgeninduced sebum secretion,hyperkeratosis of the pilosebaceous duct,microbial overgrowth in hair follicles,and inflammatory and immune reactions are closely associated with the pathogenesis of acne.However,the pathogenesis and pathophysiological processes of acne remain unclear.With the progression of scientific research,the conventional understanding of acne has been constantly updated in recent years,while clinical treatment principles underwent several transformations as well.This article aims to review some latest theories on the pathogenesis of acne vulgaris and their implications in prevention and treatment from the perspectives of sex hormone levels,hair follicular microorganisms,hair follicle stem cells and pathogenesis。