影响口腔扁平苔藓伴发胃食管反流病的因素

Influencing factors on oral lichen planus accompanied by gastroesophageal reflux disease

目的:探讨影响口腔扁平苔藓(OLP)伴发胃食管反流病(GERD)的因素。方法:选取1205例口腔扁平苔藓患者为研究对象,根据是否伴发GERD分为OLP伴发GERD组(n=182)和OLP不伴发GERD组(n=1023)。比较两组患者一般资料,分析影响OLP伴发GERD的因素。结果:1205例OLP患者中,OLP伴发GERD组共182例,GERD的发病率为15.1%(182/1205)。OLP伴发GERD组的发病年龄低于OLP不伴发GERD组(P<0.05)。OLP患者中,中年人伴发GERD的占比高于青年人和老年人(P<0.05)。OLP伴发GERD组的斑纹型和充血萎缩型占比高于OLP不伴发GERD组(P<0.05),糜烂型占比低于OLP不伴发GERD组(P<0.05)。OLP伴发GERD组中糜烂型OLP患者年龄高于斑纹型OLP(P<0.05);REU评分高于斑纹型和充血萎缩型(P<0.05)。多因素Logistic回归分析显示,年龄较小(OR=0.972,95%CI:0.967~0.978,P<0.001)、REU评分较低(OR=0.824,95%CI:0.733~0.926,P=0.001)、伴有焦虑(OR=2.388,95%CI:1.606~3.550,P<0.001)为OLP患者伴发GERD的危险因素。结论:OLP人群中GERD的发病率较高,且中年人发病率高于青年人和老年人;OLP伴发GERD患者中伴有焦虑和不伴有焦虑患者的性别构成比存在明显差异,与男性相比,女性伴发GERD患者的焦虑发病率更高;年龄较小、伴有焦虑、REU评分较低为OLP患者伴发GERD的危险因素。

Objective:To explore the influencing factors of gastroesophageal reflux disease(GERD)in patients with oral lichen planus(OLP).Methods:1,205 patients with OLP were selected as the research subjects.They were divided into two groups:OLP with gastroesophageal reflux(OLP with GERD,n=182)and OLP without GERD(OLP without GERD,n=1,023).The general information of two groups were compared,and the factors affecting the occurrence of GERD in OLP were analyzed.Results:In 1,205 OLP patients,182 cases were in OLP group with GERD,1,023 cases were in OLP group without GERD,and the incidence rate of GERD in OLP patients was 15.1%(182/1,205).The age of onset in the OLP group with GERD was lower than that in the OLP group without GERD(P<0.05).Among OLP patients,the proportion of middle-aged people with GERD was higher than that of young people and elderly people(P<0.05).The proportion of reticular type and congestive atrophy type in the OLP group with GERD was higher than that in the OLP group without GERD,and the proportion of erosive type in the OLP group with GERD was lower than that in the OLP group without GERD(P<0.05).In the OLP group with GERD,patients with erosive OLP were older than those with reticular OLP(P<0.05),and their REU scores were higher than those with reticular and congestive atrophic OLP(P<0.05).Logistic regression analysis showed that younger age(OR:0.972,95%CI:0.967~0.978,P<0.001),lower REU score(OR:0.824,95%CI:0.733~0.926,P=0.001),and accompanying anxiety(OR:2.388,95%CI:1.606~3.550,P<0.001)were risk factors for GERD in OLP patients.Conclusion:The proportion of OLP accompanied by GERD is higher than the prevalence of gastroesophageal reflux disease in the normal population in China,especially in middle-aged people who have a significantly higher prevalence than young and elderly people.The sex composition ratio of patients with and without anxiety in OLP with GERD is significantly different.Compared with men,women with GERD have a higher anxiety incidence rate.Younger age,accompanied by anxiety,and lower REU scores are risk factors for GERD in OLP patients.