不同浓度罗哌卡因应用于临床麻醉与疼痛治疗中的效果分析

Effect analysis of different concentrations of ropivacaine in clinical anesthesia and pain treatment

目的综合分析不同浓度罗哌卡因应用于临床麻醉与疼痛治疗中的效果。方法100例接受全身麻醉复合硬膜外麻醉手术治疗的患者,按照随机数字表法分为对照组与实验组,每组50例。对照组应用0.25%罗哌卡因麻醉方法,实验组应用0.2%罗哌卡因麻醉方法。比较两组患者的麻醉效果(自主呼吸恢复时间、拔管时间以及苏醒时间)、不良反应发生率、术后不同时间点的视觉模拟评分法评分以及手术前后基础生命体征有关指标(心率、动脉血氧饱和度和平均动脉压)。结果两组拔管时间比较无差异(P>0.05);实验组自主呼吸恢复时间(13.36±0.85)min以及苏醒时间(20.36±4.12)min比对照组的(16.63±1.21)、(33.96±5.48)min更短(P<0.05)。术后3、9 h,实验组视觉模拟评分法评分分别为(2.62±0.74)、(2.23±0.82)分,低于对照组的(3.31±0.81)、(3.36±1.11)分(P<0.05)。手术前及手术后,两组心率、动脉血氧饱和度和平均动脉压水平组间比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论在开展全身麻醉复合硬膜外麻醉手术治疗方法时,使用0.2%罗哌卡因的麻醉效果比0.25%罗哌卡因更理想。

Objective To comprehensively analyze the effect of different concentrations of ropivacaine on clinical anesthesia and pain treatment.Methods 100 patients who received general anesthesia combined with epidural anesthesia were divided into a control group and an experimental group according to the random numerical table method,with 75 cases in each group.The control group received 0.25%ropivacaine for anesthesia,and the experimental group received 0.2%ropivacaine for anesthesia.Patients in both groups were compared in terms of anesthesia effect(recovery time of spontaneous respiration,extubation time,and awakening time),incidence of adverse reactions,visual analogue scale score at different time points,basic vital signs related indicators(heart rate,arterial oxygen saturation,and mean arterial pressure)before and after surgery.Results There was no difference in extubation time between the two groups(P>0.05).The experimental group had recovery time of spontaneous respiration of(13.36±0.85)min and awakening time of(20.36±4.12)min,which were shorter than(16.63±1.21)and(33.96±5.48)min in the control group(P<0.05).At 3 and 9 h after surgery,the scores of visual analogue score in the experimental group were(2.62±0.74)and(2.23±0.82)points,which were lower than(3.31±0.81)and(3.36±1.11)points in the control group(P<0.05).Before and after surgery,there was no statistical significance in heart rate,arterial oxygen saturation and mean arterial pressure between the two groups(P>0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In general anesthesia combined with epidural anesthesia,the anesthetic effect of 0.2%ropivacaine is more ideal than that of 0.25%ropivacaine.