角蛋白19、C反应蛋白、白蛋白指标对结直肠癌术后疗效及预后的评估价值

Assessment Value of Keratin 19,C-Reactive Protein and Albumin Indexes on Postoperative Efficacy and Prognosis of Colorectal Cancer

目的分析角蛋白19、C反应蛋白、白蛋白检测对结直肠癌术后的临床疗效以及预测价值。方法以新疆维吾尔自治区人民医院2021年1月—2022年1月收治的98例患者为研究对象。对比临床治疗前后疗效及预后下的角蛋白19、C反应蛋白、白蛋白检测水平,通过受试者工作特征(receiveroperating characteristic,ROC)曲线评估其临床预估价值。结果治疗后,患者的角蛋白19、C反应蛋白、白蛋白水平均较治疗前下降,差异有统计学意义(P<0.05)。疗效良好组在角蛋白19、C反应蛋白水平上低于疗效欠佳组,白蛋白高于疗效欠佳组,差异有统计学意义(P<0.05)。存活组在角蛋白19、C反应蛋白水平上低于死亡组,白蛋白高于死亡组,差异有统计学意义(P<0.05)。基于ROC曲线,角蛋白19、C反应蛋白、白蛋白在最佳截断曲线下面积(area under the curve,AUC)值分别为0.822、0.921、0.899,均超过0.7,对直肠癌不良预后有预测价值。3项指标联合检测的敏感度、特异度、AUC值与约登指数均高于3项指标单一检测,差异有统计学意义(P<0.05)。结论角蛋白19、C反应蛋白、白蛋白检测能够有效预测结直肠癌患者疗效变化及预后。

Objective To analyze the clinical efficacy and predictive value of detecting keratin 19,C-reactive protein and albumin in postoperative colorectal cancer patients.Methods A total of 98 patients admitted to Xinjiang Uygur Municipal People's Hospital from January 2021 to January 2022 were selected as the study subjects.The clinical efficacy and prognosis of keratin 19,C-reactive protein,and albumin levels were compared before and after clinical treatment.The estimated clinical value was evaluated using receiver operating characteristic(ROC)curves.Results After treatment,the levels of keratin 19,C-reactive protein,and albumin in the patients decreased compared to before treatment,the differences were statistically significant(P<0.05).The levels of keratin 19 and C-reactive protein in the group with good curative effect were lower than those in the group with poor curative effect,and albumin was higher than those in the group with poor curative effect,the difference was statistically significant(P<0.05).The levels of keratin 19 and C-reactive protein in survival group were lower than those in death group,and albumin was higher than those in death group,the difference was statistically significant(P<0.05).Based on the ROC curve,the area under the curve(AUC)values of keratin 19,C-reactive protein,and albumin were 0.822,0.921 and 0.899,all exceeding 0.7,which has predictive value for poor prognosis of rectal cancer.The sensitivity,specificity,AUC value,and Yoden index of the combined detection of the three indicators were higher than those of the single detection of the three indicators,and the difference was statistically significant(P<0.05).Conclusion The detection of keratin 19,C-reactive protein,and albumin can effectively predict the changes in therapeutic efficacy and prognosis of colorectal cancer patients.