盐酸罗哌卡因联合舒芬太尼分娩镇痛对初产妇及新生儿影响的临床研究

Clinical Study on the Effects of Ropivacaine Hydrochloride Combined with Sufentanil for Labor Analgesia on Stress Response in Primiparous Women and Newborns

目的比较盐酸罗哌卡因舒芬太尼复合硬膜外麻醉分娩镇痛对初产妇应激反应及新生儿影响。方法选取2022年10月至2023年10月仙桃市妇幼保健院妇产科的60例初产妇,随机划分为研究组(盐酸罗哌卡因舒芬太尼复合硬膜外麻醉分娩镇痛)与对照组(罗哌卡因方案),每组各30例,比较两组应激反应指标,随访镇痛效果、1和5 min时Apgar评分、不良反应发生率。结果研究组舒张压、收缩压、心率指标均明显低于对照组,差异有统计学意义(P<0.05);分娩镇痛后研究组镇痛效果低于对照组,差异有统计学意义(P<0.05);干预后两组的新生儿1min、5min评分对比差异无统计学意义(P>0.05);研究组不良反应总发生率1例(3.33%),低于对照组的10例(33.33%),差异有统计学意义(P<0.05)。结论对接受硬膜外分娩镇痛的初产妇行盐酸罗哌卡因舒芬太尼复合硬膜外麻醉,有利于缩短第一产程活跃期,改善镇痛效果,降低不良反应的发生率,不影响产妇运动神经和新生儿健康,安全性更高。

Objective Comparing the effects of ropivacaine hydrochloride and sufentanil combined with epidural anesthesia for labor analgesia on stress response in primiparous and neonatal outcomes.Methods The 60 primiparous women included were from the Obstetrics and Gynecology department of our hospital from October 2022 to October 2023.They were randomly divided into the study group(ropivacaine hydrochloride sufentanil combined with epidural anesthesia for delivery analgesia)and the control group(ropivacaine regimen),with 30 cases in each group.The stress response indicators,pain relief effect,Apgar score at 1 and 5 minutes,and incidence of adverse reactions were compared between the two groups.Results The diastolic blood pressure,systolic blood pressure,and heart rate indicators in the study group were significantly lower than those in the control group,and the statistical results showed significant differences(P<0.05);The analgesic effect of the study group after childbirth was lower than that of the control group,and the statistical results showed a significant difference(P<0.05);After intervention,there was no statistically significant difference in scores between the two groups of newborns at 1 and 5 minutes(P>0.05);The total incidence of adverse reactions in the study group was 1 case(3.33%),which was lower than that in the control group of 10 cases(33.33%),and the statistical results showed a significant difference(P<0.05).Conclusion Performing ropivacaine hydrochloride combined with sufentanil epidural anesthesia for primiparous undergoing epidural delivery analgesia is beneficial for shortening the active period of the first stage of labor,improving analgesic effects,reducing the incidence of adverse reactions,and not affecting maternal motor nerves and newborn health,which is very safe.