摘要
目的分析正电子药物合成器合成基氟-18标记的四乙酰脱氧葡糖[1,3,4,6-四乙酰基-O-2-^(18)F-2-脱氧-β-D葡萄糖,简称^(18)F-FDG-(OAc)_(4)]的稳定性和实用性。方法基于合成器及其合成工艺流程,进行^(18)F-FDG-(OAc)4合成产量和质量控制及其与氟-18标记的脱氧葡萄糖(2-[18F]-氟-2-脱氧-D-葡萄糖,简称18F-FDG)在小鼠体内的生物分布异同分析。结果连续3批合成^(18)F-FDG-(OAc)4的成功率为100%,产率分别为59.64%、60.61%、59.72%,产品溶液为无色透明溶液,放射性化学纯度≥96%(Rf值为0.8~0.9),放射性核纯度为100%。^(18)F-FDG-(OAc)_(4)与18F-FDG注入小鼠,后各个脏器的放射性摄取均无差别,差异无统计学意义(P>0.05)。结论正电子药物合成器合成^(18)F-FDG-(OAc)4的流程简单、便捷,合成成功率和合成产率较高,具有较强的稳定性和实用性。
Objective To analyze the stability and practicality of the positron emission tomography drug synthesizer for the synthesis of ^(18)F-FDG-(OAc)4.Methods Based on the synthesizer and its synthetic process,the synthesis yield and quality control of ^(18)F-FDG-(OAc)_(4) were carried out,and the similarities and differences in biological distribution in mice between ^(18)F-FDG-(OAc)_(4) and ^(18)F-FDG were analyzed.Results The success rate of ^(18)F-FDG-(OAc)_(4) in 3 consecutive batches was 100%,and the yields were 59.64%,60.61%,and 59.72%,respectively.The product solution was colorless and transparent,with radioactive chemical purity was≥96%(Rf value was 0.8-0.9)and radioactive nuclear purity was 100%.There were no significant differences in the radioactive uptake of various organs after injecting ^(18)F-FDG-(OAc)_(4) and 18F-FDG into mice(P>0.05).Conclusion The synthesizer provides a simple and convenient process for the synthesis of ^(18)F-FDG-(OAc)_(4) with high synthesis success rate and yield,showing strong stability and practicality.
作者
何正中
庞丁华
李宁
张实来
杨洪
蒙小飞
杨志
肖国有
HE Zhengzhong;PANG Dinghua;LI Ning;ZHANG Shilai;YANG Hong;MENG Xiaofei;YANG Zhi;XIAO Guoyou(Department of Nuclear Medicine(Guangxi Clinical Key Specialty),Guangxi Medical University Cancer Hospital,Nanning Guangxi 530021,China)
出处
《中国医疗设备》
2024年第5期26-30,共5页
China Medical Devices
基金
广西科技计划项目重点研发计划(桂科AB19110015)
广西生物靶向诊治研究重点实验室开放基金课题(GXSWBX202203,GXSWBX202204,GXSWBX202205)
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190559,Z-A20220680,Z-A20220678)
广西高校中青年教师科研基础能力提升项目(2023KY0084)
广西医科大学青年科学基金项目(GXMUYSF202226,GXMUYSF202356)。
