鼻内镜下鼻后神经切断术治疗变应性鼻炎的效果

Effect of posterior nasal neurotomy under nasal endoscope in the treatment of allergic rhinitis

目的探讨鼻内镜下鼻后神经切断术治疗变应性鼻炎(AR)的效果。方法选取2020年1月至2021年12月本院收治的80例AR患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,各40例。对照组实施常规治疗,观察组实施鼻内镜下鼻后神经切断术联合常规治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的白细胞介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的喷嚏、鼻溢、鼻塞、鼻结膜炎相关生存质量问卷(RQLQ)及视觉模拟评分法(VAS)评分均低于对照组(P<0.05)。治疗后,观察组的鼻腔阻力(NR)、鼻腔黏液纤毛传输时间(MTT)、鼻黏膜纤毛清除率(NMCR)及嗜酸性粒细胞阳离子蛋白(ECP)水平均低于对照组(P<0.05)。结论鼻内镜下鼻后神经切断术可有效减轻AR患者的临床症状及炎症反应,改善生存质量,恢复鼻腔生理功能。

Objective To investigate the effect of posterior nasal neurotomy under nasal endoscope in the treatment of allergic rhinitis(AR).Methods A total of 80 AR patients admitted in our hospital from January 2020 to December 2021 were selected as the research objects.According to the parity of admission number,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with routine treatment,and the observation group was treated with posterior nasal neurotomy under nasal endoscope combined with routine treatment.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-5(IL-5),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After treatment,the scores of sneezing,rhinorrhea,nasal congestion,Related Quality of Life Questionnaire(RQLQ)and Visual Analogue Score(VAS)in the observation group were lower than those in the control group(P<0.05).After treatment,the nasal resistance(NR),mucociliary transport time(MTT),nasal mucociliary clearance rate(NMCR)and eosinophil cationic protein(ECP)level in the observation group were lower than those in the control group(P<0.05).Conclusion Posterior nasal neurotomy under nasal endoscope can effectively reduce the clinical symptoms and inflammatory response of AR patients,improve the quality of life and restore the physiological function of nasal cavity.