糖化血红蛋白、空腹血糖联合检测在糖尿病诊断中的应用价值

Application Value of Combined Glycosylated Hemoglobin and Fasting Blood Glucose Test in Diabetes Diagnosis

目的:探讨糖化血红蛋白、空腹血糖联合检测在糖尿病诊断中的应用价值。方法:选取2022年6—10月上海市宝山区吴淞街道社区卫生服务中心收治的疑似糖尿病患者200例以及体检健康者100例作为研究对象,均进行糖化血红蛋白与空腹血糖检测,以临床综合诊断结果为“金标准”,分析糖化血红蛋白、空腹血糖以及两者联合检测对糖尿病的诊断效能,比较糖尿病患者与体检健康者糖化血红蛋白与空腹血糖水平。结果:200例疑似糖尿病患者经综合诊断,确诊糖尿病180例。糖化血红蛋白、空腹血糖联合检测诊断糖尿病的准确率、特异度、阳性预测值、阴性预测值高于糖化血红蛋白、空腹血糖单一检测,误诊率、漏诊率低于糖化血红蛋白、空腹血糖单一检测,差异有统计学意义(P<0.05)。糖尿病患者糖化血红蛋白、空腹血糖水平高于体检健康者,差异有统计学意义(P<0.05)。结论:糖化血红蛋白、空腹血糖联合检测应用于糖尿病诊断中的价值较高,可提高准确率、特异度、阳性预测值、阴性预测值,减少漏诊与误诊,有助于临床诊疗工作的顺利开展。

Objective:To explore the application value of combined test of glycosylated hemoglobin and fasting blood glucose in the diagnosis of diabetes.Methods:A total of 200 suspected diabetic patients admitted to Shanghai Baoshan District Wusong Street Community Health Service Center from June 2022 to October 2022 and 100 healthy subjects for physical examination were selected as the study subjects.All patients and healthy subjects received glycosylated hemoglobin and fasting blood glucose test.Clinical comprehensive diagnosis results were used as the"gold standard"to analyze the diagnostic efficiency of glycosylated hemoglobin,fasting blood glucose and combined test for diabetes mellitus.The glycosylated hemoglobin and fasting blood glucose levels of diabetic patients and healthy subjects were compared.Results:Comprehensive diagnosis of 200 suspected diabetic patients showed that,180 cases were diagnosed with diabetes.The accuracy,specificity,positive predictive value and negative predictive value of the combined test of glycosylated hemoglobin and fasting blood glucose in the diagnosis of diabetes mellitus were higher than those of glycosylated hemoglobin test alone and fasting blood glucose test alone,and the misdiagnosis rate and missed diagnosis rate of the combined test were lower than those of glycosylated hemoglobin test alone and fasting blood glucose test alone,and the difference was statistically significant(P<0.05).The levels of glycosylated hemoglobin and fasting blood glucose in diabetic patients were higher than those in healthy subjects,patients,and the difference was statistically significant(P<0.05).Conclusion:The combined test of glycosylated hemoglobin and fasting blood glucose has high value in the diagnosis of diabetes,and can improve the accuracy,specificity,positive predictive value and negative predictive value,reduce missed diagnosis and misdiagnosis,and contribute to the smooth development of clinical diagnosis and treatment.