轻度认知功能障碍与肌少症相关性

Research advances on the correlation between mild cognitive impairment and sarcopenia

轻度认知功能障碍(MCI)是介于正常认知水平和痴呆的一种异常的中间状态,肌少症是一类进行性和广泛性的骨骼肌疾病,可能增加老年人跌倒、骨折、衰弱等不良结果的发生。认知功能障碍及肌少症均属于较为常见的老年综合征。近年有研究发现,肌少症的存在可能增加认知功能障碍的发生。本文将从流行病学特征、诊断、轻度认知功能障碍与肌少症之间的可能关联以及两者间可能存在的作用机制进行论述。

Mild cognitive impairment(MCI)is a transitional stage of cognitive abnormality between the normal cognitive function level and dementia,often involving impairment in one or more cognitive domains.Sarcopenia is a type of progressive and common skeletal muscle disorder and may increase the occurrence of adverse outcomes such as falls,bone fractures and frailty in older adults.Both cognitive dysfunction and sarcopenia are among common geriatric syndromes.Studies in recent years have found that the presence of sarcopenia may increase the occurrence of cognitive dysfunction.This article discussed the epidemiological characteristics and diagnosis of MCI and sarcopenia,the possible relationship between them,and potential mechanisms underlying the interaction between them.