孕妇妊娠早期血清25-羟维生素D水平与围生期抑郁及骨密度的关系

The relationship between serum 25 hydroxyvitamin D levels in early pregnancy of pregnant women and perinatal depression and bone density

目的探讨妊娠早期血清25-羟维生素D水平与围生期抑郁及骨密度的关系。方法选取在本院建档的120例单胎妊娠早期孕妇为研究对象,通过资料收集,采集孕妇静脉血,采用放射免疫法检测血清25-羟维生素D水平,根据血清25-羟维生素D水平将孕妇分为维生素D正常组、维生素D不足组、维生素D缺乏组和维生素D严重缺乏组,各30例,比较各组的抑郁程度、骨密度水平。结果维生素D正常组血清25-羟维生素D水平、T-Score指标均高于维生素D不足组、维生素D缺乏组、维生素D严重缺乏组,爱丁堡产后抑郁量表评分低于维生素D不足组、维生素D缺乏组、维生素D严重缺乏组,差异有统计学意义(P<0.05);Pearson相关分析显示,妊娠早期孕妇血清25-羟维生素D水平与抑郁、骨密度呈显著正相关(r=0.273、r=0.726,P<0.05)。结论妊娠早期血清25-羟维生素D水平与围生期抑郁及骨密度有直接影响,由此注重妊娠早期血清25-羟维生素D水平变化,可能减少围生期抑郁及骨质疏松症的发生。

Objective To explore the relationship between serum 25 hydroxyvitamin D levels in early pregnancy and perinatal depression and bone density.Methods 120 early single pregnancy pregnant women registered in our hospital were selected as the research subjects.Through data collection,venous blood was collected from pregnant women,and serum 25 hydroxyvitamin D levels were detected using radioimmunoassay.According to serum 25 hydroxyvitamin D levels,pregnant women were divided into normal vitamin D group,vitamin D deficiency group,vitamin D deficiency group,and vitamin D severe deficiency group,30 cases each.The depression level and bone density level of each group were compared.Results The serum 25 hydroxyvitamin D levels and T-score index of the normal vitamin D group were higher than those of the vitamin D deficiency group,vitamin D deficiency group,and severe vitamin D deficiency group.The Edinburgh Postpartum Depression Scale score was lower than that of the vitamin D deficiency group,vitamin D deficiency group,and severe vitamin D deficiency group,and the difference was statistically significant(P<0.05);Pearson correlation analysis showed that serum 25 hydroxyvitamin D levels in early pregnancy women were significantly positively correlated with depression and bone density(r-0.273,r-0.726,P<0.05).Conclusion The serum 25 hydroxyvitamin D levels in early pregnancy have a direct impact on perinatal depression and bone density.Therefore,paying attention to changes in serum 25 hydroxyvitamin D levels in early pregnancy may reduce the occurrence of perinatal depression and osteoporosis.