谓葆颗粒联合培菲康治疗小儿功能性腹痛临床疗效及对焦虑抑郁情绪的影响

Clinical efficacy of Weibao granule combined with Perficon in treatment of functional abdominal pain and its impact on anxiety and depression in children

目的探讨功能性腹痛患儿应用谓葆颗粒联合培菲康治疗的疗效及对患儿焦虑抑郁情绪影响。方法共计纳入102例功能性腹痛患儿(2019年3月—2023年9月入住湖北省妇幼保健院儿童消化内科),以随机数字表法分为观察组、对照组,每组51例。对照组患儿采取培菲康治疗,观察组患儿采取谓葆颗粒联合培菲康治疗。2组患儿治疗前后的结果,包括:疗效、腹痛及食欲不振、面色苍白等症状消失时间、儿童焦虑性情绪障碍筛查量表(SCARED)、儿童抑郁障碍自评量表(DSRSC)评分、不良反应。结果对照组与观察组患儿总有效率分别为84.31%、96.08%,观察组有效率高于对照组(P<0.05);观察组患儿腹痛及食欲不振、面色苍白等症状消失时间分别为(7.86±1.96)d、(4.95±0.38)d、(3.89±0.47)d,均短于对照组患儿[(10.45±1.15)d、(5.72±0.62)d、(5.10±0.38)d,P<0.05];治疗后观察组患儿SCARED及DSRSC评分分别为(10.15±1.52)分、(9.45±1.07)分,均低于对照组患儿[(17.49±2.95)分、(14.23±1.87)分,P<0.05];对照组与观察组患儿不良反应发生率分别为3.92%、1.96%,差异无统计学意义(P>0.05)。结论谓葆颗粒联合培菲康治疗小儿功能性腹痛临床疗效良好,患儿恢复快,还可较好改善患儿不良情绪,不良反应发生率较低,安全可靠。

Objective To explore the efficacy of Weibao granule combined with Perficon in the treatment of children with functional abdominal pain and its impact on anxiety and depression in children.Methods A total of 102 children with functional abdominal pain admitted to Department of Pediatric Gastroenterology,Hubei Maternal and Child Health Hospital from March 2019 to September 2023 were included and randomized into the observation group and control group,with 51 in each group.The children in the control group were treated with Perficon and those in the observation group were treated with Weibao granule combined with Perficon.The efficacy,time to resolution of symptoms,screen for child anxiety related emotional disorders(SCARED),depression self-rating scale for children(DSRSC)score,occurrence of adverse reactions were compared between the 2 groups.Results The total effective rate was significantly higher in the observation group than that in the control(84.31%vs 96.08%,P<0.05).The time to disappearance of symptoms such as abdominal pain,loss of appetite,and pale complexion in the observation group were(7.86±1.96)d,(4.95±0.38)d and(3.89±0.47)d,respectively,which were significantly shorter than those in the control((10.45±1.15)d,(5.72±0.62)d,(5.10±0.38)d,P<0.05).After treatment,the SCARED and DSRSC scores in the observation group were(10.15±1.52)points and(9.45±1.07)points,respectively,which were remarkably lower than those in the control((17.49±2.95)points and(14.23±1.87)points,P<0.05).The occurring rate of adverse reaction was 3.92% in the observation group and 1.96% in the control,showing no statistical difference(P>0.05).Conclusion Weibao granule combined with Perficon has good clinical efficacy in treating functional abdominal pain in children because it can quickly promote the recovery of children,better improve the children’s bad mood and its rate of adverse reaction is low.Therefore,it is safe and reliable.