期刊文献+

响应面优化提取新鲜沙棘果中异鼠李素及其两性聚合物结构修饰

Response Surface Methodology Extraction of Isorhamnetin from Fresh Seabuckthorn and Design of Isorhamnetin Zwitterionic Polymers
下载PDF
导出
摘要 目的:建立响应面优化提取新鲜沙棘果中异鼠李素的方法,采用高分子两性聚合物修饰异鼠李素。方法:采用Design-Expert 8.0.6软件及其Box-Behnken优化从新鲜沙棘果中提取异鼠李素,制备的异鼠李素采用自组装模式制成两性聚合物。结果:优化的提取温度为75℃,提取时间60 min,100 g新鲜沙棘果中盐酸加入量35 mL;采用自组装模式制成异鼠李素两性聚合物反应完全,溶解度良好。结论:响应面法稳定可行,可用于新鲜沙棘果中异鼠李素工艺优化;自组装模式制成异鼠李素两性聚合物结构修饰可行。 Objective:To establish a response surface optimization method for extracting isorhamnetin from fresh seabuckthorn fruits,and modify isorhamnetin with a high molecular amphoteric polymer.Methods:Design Expert 8.0.6 software and Box Behnken optimization were used to extract isorhamnetin from fresh seabuckthorn fruit,and the prepared isorhamnetin was self-assembled into an amphoteric polymer.Results:The optimized extraction temperature is 75℃,extraction time is 60 minutes,and the amount of hydrochloric acid added to 100g of fresh seabuckthorn fruit is 35 mL;The use of self-assembly mode to produce isothamnetin amphoteric polymer has complete reaction and good solubility.Conclusion:The response surface method is stable and feasible,and can be used to optimize the process of isorhamnetin in fresh seabuckthorn fruit;The self-assembly mode is feasible for the structural modification of isothamnetin amphoteric polymers.
作者 赵磊 丁雪 孙艳杰 马金刚 孟军 姜大成 昝珂 杨铭 ZHAO Lei;DING Xue;SUN Yan-jie;MA Jin-gang;MENG Jun;JIANG Da-cheng;ZAN Ke*;YANG Ming(Changchun University of traditional Chinese Medicine School of Medicine,Jilin Changchun130117,China;Siping Institute for Food and Drug Control,Jiling Siping 136000,China;Jilin Normal University College of Chemistry,Jilin Siping 136000,China;Siping Central People′s Hospital,Jiling Siping 136000,China;Jilin Medical Device Inspection and Research Institute,Jilin Changchun 130041,China;National Institutes for Food and Drug Control,Beijing 102629,China;Jining Reserarch Institute for Food and Drug Inspection and Testing,Shandong Jining 272000,China)
出处 《中国药物评价》 2024年第2期141-147,共7页 Chinese Journal of Drug Evaluation
基金 吉林省中药材标准,项目名称:新鲜沙棘果(JLYC-2021-024) 吉林省发改委产业技术研究与开发项目(No.2020C037-3) 吉林省道地药材实体标本库和数字化信息平台建设。
关键词 响应面优化 新鲜沙棘果 异鼠李素 两性聚合物 Response Surface Methodology Fresh Seabuckthorn Isorhamnetin Zwitterionic Polymers
  • 引文网络
  • 相关文献

参考文献16

二级参考文献268

共引文献112

;
使用帮助 返回顶部