二丁二仙汤加减联合环丙沙星对肾盂肾炎患者免疫应答功能的影响

Effect of Erding Erxian Decoction Combined with ciprofloxacin on immune response in patients with pyelonephritis

目的:探究二丁二仙汤加减联合环丙沙星对肾盂肾炎患者免疫应答功能的影响。方法:选取2022年7月~2023年7月我院接诊的148例肾盂肾炎患者作为研究对象,按照双盲法分为环丙沙星组和联合治疗组各74例。环丙沙星组采用环丙沙星进行治疗,联合治疗组在环丙沙星组基础上加服二丁二仙汤加减进行治疗。观察两组患者临床症状体征消失时间、生活质量、中医症候积分及治疗效果;采用全自动生化分析仪检测血肌酐(Scr)、尿素氮(BUN)水平;炎性因子白细胞介素-6(IL-6)、子白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平;酶联免疫吸附双抗体夹心法检测血清免疫球蛋白IgA、IgG、IgM水平。结果:与环丙沙星组相比,联合治疗组临床症状体征消失时间较短(P<0.05)。与环丙沙星组相比,联合治疗组肾功能指标Scr、BUN及炎性因子IL-6、IL-17、TNF-α水平,中医症候积分较低(P<0.05)。与环丙沙星组相比,联合治疗组免疫球蛋白IgA、IgG、IgM水平,生活质量评分及治疗总有效率较高(P<0.05)。结论:二丁二仙汤加减联合环丙沙星可有效改善肾盂肾炎患者临床症状,增强免疫应答功能,可用于此病的治疗中。

Objective:to explore the effect of Erding Erxian Decoction Combined with ciprofloxacin on immune response function of patients with pyelonephritis.Methods:148patients with pyelonephritis in our hospital from July 2022to July 2023were selected as the research objects,and they were divided into ciprofloxacin group and combined treatment group with 74cases in each group.Ciprofloxacin group was treated with ciprofloxacin,and the combined treatment group was treated with Erding Erxian Decoction on the basis of ciprofloxacin group.The disappearance time of clinical symptoms and signs,quality of life,TCM symptom score and treatment effect of the two groups were observed;the levels of serum creatinine(SCR)and urea nitrogen(BUN)were detected by automatic biochemical analyzer;inflammatory factor interleukin-6(IL-6)were detected by enzyme-linked immunosorbent assay(ELISA)The levels of interleukin-17(IL-17)and tumor necrosis factor-α(TNF-α)were detected;the levels of serum immunoglobulin IgA,IgG and IgM were detected by enzyme-linked immunosorbent assay.Results:Compared with ciprofloxacin group,the disappearance time of clinical symptoms and signs in the combined treatment group was shorter(P<0.05).Compared with ciprofloxacin group,SCR,bun,IL-6,IL-17,TNF-αlevels and TCM syndrome score of combined treatment group were lower(P<0.05).Compared with ciprofloxacin group,the levels of immunoglobulin IgA,IgG,IgM,quality of life score and total effective rate of treatment in the combined treatment group were higher(P<0.05).Conclusion:Erding Erxian Decoction Combined with ciprofloxacin can effectively improve the clinical symptoms of patients with pyelonephritis and enhance the immune response function,which can be used in the treatment of this disease.