维生素D受体在心肌缺血再灌注损伤中的作用分析

Role of Vitamin D Receptor in Myocardial Ischemia-reperfusion Injury

目的探究维生素D受体在心肌缺血再灌注损伤中的作用。方法南昌大学医学部于2022年9月—2023年9月将40只野生雌性C57BL/6小鼠纳入研究中,按随机数表法分为对照组及观察组,每组20只。对照组予以腹腔注射Vehicle,观察组予以腹腔注射维生素D受体(Vitamin D Receptor,VDR)生理性激动剂。灌注完毕24 h后,比较两组血流动力学、心功能指标及心肌梗死面积变化情况。结果观察组灌注24 h心肌梗死面积(24.50±3.24)%,低于对照组(42.36±3.25)%,差异有统计学意义(t=24.614,P<0.05);观察组标准摄取值(Standardized Uptake Values,SUV)、左心室短轴缩短率(Left Ventricular Fractional Shortening,LVFS)、左心室射血分数(Left Ventric ular Ejection Fractions,LVEF)水平均高于对照组,差异有统计学意义(t=6.773、39.714、24.494、P均<0.05);两组心率、平均动脉压对比,差异无统计学意义(P均>0.05)。结论在心肌缺血再灌注损伤中,通过使用药物激活维生素D受体可以减轻其损伤程度,具有一定的研究价值,可采取进一步探讨研究。

Objective To explore the role of vitamin D receptor in myocardial ischemia-reperfusion injury.Methods Medical Science Center of Nanchang University conducted a study from September 2022 to September 2023.A total of 40 wild female C57BL/6 mice were included in the study and divided into control group and observation group by random number table method,with 20 mice in each group.The control group was given intraperitoneal injection of Vehicle,and the observation group was given intraperitoneal injection of vitamin D receptor(VDR)physiological agonist.The changes of hemodynamics,cardiac function indexes and myocardial infarction size in the two groups were compared 24 h after perfusion.Results The 24 h after perfusion myocardial infarction area(24.50±3.24)%in the observation group was lower than that in the control group(42.36±3.25)%,and the difference was statistically significant(t=24.614,P<0.05).The levels of standardized uptake values(SUV),left ventricular fractional shortening(LVFS)and left ventric-ular ejection fractions(LVEF)in observation group were higher than those in control group,and the differences were statistically significant(t=6.773,39.714,24.494,all P<0.05).There were no significant differences in heart rate and mean arterial pressure between the two groups(both P>0.05).Conclusion In myocardial ischemia-reperfusion injury,activating vitamin D receptor with drugs can reduce the degree of injury,which has certain research value and can be further studied.