艾司西酞普兰联合焦点解决短程治疗对青少年抑郁患者负性情绪、认知功能的影响

Effects of focal solution short-course treatment plus escitalopram on negative mood and cognitive function for adolescent patients with depression

目的分析艾司西酞普兰联合焦点解决短程治疗对青少年抑郁患者负性情绪、认知功能的影响。方法选取2021年12月至2023年6月在杭州市第七人民医院就诊的60例抑郁症青少年患者,根据随机数字表法分为观察组(30例)和对照组(30例)。对照组使用艾司西酞普兰治疗,观察组在对照组治疗的基础上联合焦点解决短程治疗。对比两组患者的临床疗效、负性情绪、认知功能、不良反应。结果治疗后2~6周两组患者健康问卷评分均降低,观察组较对照组更优(均P<0.05);两组的汉密尔顿抑郁量表评分、广泛性焦虑自评量表评分均降低,观察组较对照组更低(均P<0.05);两组的精神状态评定量表评分均上升,观察组较对照组的认知功能更优(均P<0.05)。与对照组相比,观察组的不良反应总发生率更低(P<0.05)。结论艾司西酞普兰联合焦点解决短程治疗不仅可缓解青少年抑郁患者的焦虑和负面情绪,还能提高患者的认知功能,降低不良反应发生率,值得在临床推广应用。

Objective To investigate the effects of focused solution short-course therapy plus escitalopram on negative mood and cognitive function in adolescent patients with depression.Methods Sixty adolescent patients with depression who attended the Hangzhou Seventh People's Hospital from December 2021 to June 2023 were randomly divided into the study group and the control group with 30 cases in each group.The control group was treated with escitalopram alone,and the study group received focal solution short-course treatment plus escitalopram.The clinical efficacy,negative mood,cognitive function,and adverse reactions of the two groups were compared.Results Patient health questionnaire(PHQ-9)scores decreased in both groups from 2 to 6 weeks after treatment,and the PHQ-9 scores were better in the study group than those in the control group(all P<0.05).Hamilton depression scale(HAMD)scores and generalized anxiety self Rating Scale(GAD-7)scores were reduced in both groups from 2 to 6 weeks after treatment,and GAD-7 scores were lower in the study group than those in the control group(all P<0.05).The mental state measurement scale(MMSE)scores increased in both groups from 2 to 6 weeks after treatment,and the MMSE scores in the study group were better than those in the control group(all P<0.05).The total incidence of adverse reactions was lower in the study group compared with the control group(P<0.05).Conclusion The focal solution short-course treatment plus escitalopram can relieve anxiety and negative emotion,improve cognitive function and reduces the incidence of adverse effects in adolescent depression patients, which is worthy of promoting in clinic application.