基于“主客浑受”学说探析胰腺癌之发生发展及转移

Development and metastasis of pancreatic cancer based on the doctrine of“subject-object interaction”

胰腺癌素被冠有“癌王”之称,其起病隐匿,发病率及病死率在国内外均具有上升趋势。癌浊之毒损及胰腑,总以湿热、血瘀二者胶结,相因为患,脾气亏虚,气机壅遏,阴阳气不相顺接为要。“主客浑受”学说由清代温病学家薛生白提出,主要描述为湿热交作,瘀热互结,脉络受损,阴血耗伤之象,以通络祛瘀,清热化湿为治疗总则,辅以行气散结,益气扶正,培补营血。笔者通过临床观察及复习文献资料发现,“主客浑受”所阐释的病理状态与胰腺癌的发展、转移具有高度相似之处,文章试通过“主客浑受”学说浅析胰腺癌发展转移规律及治则治法。

Pancreatic cancer is known as the“king of cancers”and has an insidious onset with an increasing morbidity and mortality rate at home and abroad.The toxicity of cancer is the root of cancerous toxin damage to the pancreas and internal organs,always with dampness and heat,blood stasis and the two agglutination,because of the disease,the deficiency of spleen qi,the congestion of qi,and yin and yang qi are not smooth to the key.The doctrine of“subject and guest are in harmony”was put forward by XUE Shengbai,a Qing Dynasty therapeutic scientist,and is mainly described as a symptom of dampness and heat gumming up,stasis and heat intermingling,damage to the veins and channels,and depletion of yin and blood,with the general principle of treatment of clearing heat and dampness by clearing the channels and removing stasis,supplemented by moving qi and dispersing knots,benefiting qi and helping to correct the situation,and nourishing the yin and blood.Through clinical observation and review of literature,the author found that the pathological state explained by“subject and guest are in harmony with each other”,which is highly similar to the development and metastasis of pancreatic cancer.A test case is also attached to help support the evidence.