肠道菌群与胰腺癌发病机制及诊治的研究进展

Research progress of intestinal flora and pathogenesis,diagnosis and treatment of pancreatic cancer

胰腺癌(PAAD)是较为常见的消化道恶性肿瘤,其发病率和死亡率逐年升高,虽然经多年的研究及探索,但PAAD的预后并未得到明显改善。近年来,学者们研究了肠道菌群在PAAD发病过程中的变化及可能的作用机制,结果表明肠道菌群变化与胰腺疾病之间的关系具有重要的临床意义,肠道微生态将成为PAAD诊断和治疗的新方向,肠道菌群有望成为PAAD早期诊断的标志物,为PAAD的防治、干预和治疗提供科学的临床依据,这可能为生物标志物和靶向治疗开辟一条新途径。本文总结了肠道菌群与PAAD发病机制和诊治的最新研究进展,并分析该研究的发展趋势。

Pancreatic cancer is a common malignant tumor of the digestive tract,and its incidence and mortality are increasing year by year.Despite years of research and exploration,the prognosis of pancreatic cancer has not been significantly improved.In recent years,scholars have studied the changes and possible mechanisms of intestinal flora in the pathogenesis of pancreatic cancer,the results show that the relationship between the changes of intestinal flora and pancreatic disease has important clinical significance.Intestinal microecology will become a new direction for the diagnosis and treatment of pancreatic cancer,andit is expected to be a marker for the early diagnosis of pancreatic cancer.It provides a scientific clinical basis for the prevention,intervention and treatment of pancreatic cancer.In recent years,scholars have studied the changes and possible mechanisms of intestinal flora in the pathogenesis of pancreatic cancer.The results show that the relationship between the changes of intestinal flora and pancreatic disease has important clinical significance.Intestinal microecology will become a new direction for the diagnosis and treatment of pancreatic cancer.It provides a scientific clinical basis for the prevention,intervention and treatment of pancreatic cancer,which may open up a new way for biomarkers and targeted therapy.The article summarizes the latest research progress of intestinal flora in the pathogenesis,diagnosis and treatment of pancreatic cancer,and analyzes the development trend of this research.