小儿咳喘灵颗粒联合布地奈德雾化吸入治疗咳嗽变异性哮喘的效果及安全性分析

Effect and safety analysis of Xiaoer Kechuanling Granule combined with budesonide aerosol inhalation in the treatment of cough variant asthma

目的分析小儿咳喘灵颗粒联合布地奈德雾化吸入治疗咳嗽变异性哮喘的效果及安全性。方法选择2020年3月—2022年4月医院收治的79例咳嗽变异性哮喘患儿,根据治疗方法不同分为观察组(n=41)与对照组(n=38)。对照组接受布地奈德气雾化吸入治疗,观察组在对照组的基础上接受小儿咳喘灵颗粒治疗,对比2组患儿的临床疗效、肺功能、气道炎症指标及安全性。结果观察组总有效率(95.12%)高于对照组(78.95%)(P<0.05)。治疗前,2组第一秒用力呼气容积/用力肺活量(FEV1/FVC)、FVC差异无统计学意义(P>0.05);治疗后,2组FEV1/FVC、FVC均高于治疗前(P<0.05),且观察组高于对照组(P<0.05)。治疗前,2组CD3+、CD4+、CD8+水平差异无统计学意义(P>0.05);治疗后,2组CD3+、CD4+细胞水平均高于治疗前(P<0.05),且观察组高于对照组(P<0.05);治疗后,2组CD8+细胞水平均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。2组不良反应总发生率差异无统计学意义(P>0.05)。结论小儿咳喘灵颗粒联合布地奈德雾化吸入治疗咳嗽变异性哮喘效果确切,可改善患儿肺功能和免疫功能,安全可靠。

Objective To analyze the efficacy and safety of Xiaoer Kechuanling granule combined with budesonide aerosol inhalation in the treatment of cough-variant asthma.Methods A total of 79 children with cough variant asthma admitted to a hospital from March 2020 to April 2022 were divided into observation group(n=41)and control group(n=38)according to different treatment methods.The control group received budesonide aerosol inhalation treatment,and the observation group received Xiaoer Kechuanling granules besides the treatment of control group.The clinical efficacy,lung function,airway inflammation indicators and safety of the two groups were compared.Results The total effect rate of observation group(95.12%)was higher than control group(78.95%)(P<0.05).Before treatment,there was no statistical difference in forced expiratory volume/forced vital capacity(FEV1/FVC)and FVC between the two groups(P>0.05).After treatment,FEV1/FVC and FVC in 2 groups were higher than before treatment(P<0.05),and the observation group was higher than control group(P<0.05).Before treatment,there was no statistical difference in the levels of CD3+,CD4+and CD8+cells between two groups(P>0.05).After treatment,the levels of CD3+and CD4+cells in two groups were higher than before treatment(P<0.05),and the observation group was higher than control group(P<0.05).After treatment,CD8+cells levels in two groups were lower than before treatment(P<0.05),and observation group was lower than control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Xiaoer Kechuanling Granule and budesonide aerosol inhalation was effective in the treatment of cough variant asthma,which could improve the lung function and immune function and was safe and reliable.