基于“五原则”的泽泻汤质量标志物(Q-marker)预测分析

Predictive Analysis on Quality Markers(Q-Marker)of ZeXie Decoction Based on“Five Principles”

泽泻汤由泽泻和白术两味药组方,为利水除饮,健脾制水的经典名方,具有利尿、抗结石、保肾护肝、降血脂、降血糖、抗炎等药理作用,现代临床多应用于治疗高血压病、高血脂症、眩晕病和脑供血不足等疾病。本文在文献基础上,结合中医理论,基于“五原则”理论,从质量传递与溯源、成分特有性、成分与有效性关联、复方配伍环境和成分可测性这五个方面对泽泻汤的质量标志物(Q-marker)进行预测分析,以期为泽泻汤质量控制研究提供参考依据。

ZeXie decoction is a traditional Chinese medicine prescription,composed of two herbs:ZeXie and BaiZhu,which can be used to promote diuresis and eliminate fluid retention,and invigorating the spleen to make water.It has pharmacological effects such as diuresis,anti calculi,kidney and liver protection,lowering blood lipids,lowering blood sugar,and anti-inflammatory.And the clinical studies have also showed ZeXie decoction was effective for the treatment of hypertension,hyperlipidemia,dizziness,and cerebral blood supply deficiency,etc.Based on literatures and guided by traditional Chinese medicine theory,this article predicts and analyzes the quality markers(Q-markers)of ZeXie decoction from five principles:quality transmission and traceability,component specificity,correlation between components and effectiveness,compound compatibility environment,and component measurability,in order to provide reference basis for the quality control research of ZeXie decoction.