摘要
人乳头瘤病毒(HPV)是一种具有特殊嗜上皮性的微小无包膜环状双链DNA病毒,是女性常见的性传播疾病之一,目前已发现200多种不同的HPV基因型。持续性高危型HPV感染与宫颈、阴道上皮内瘤变及宫颈癌密切相关,早期缺乏典型临床症状,严重危害女性健康。最新研究将HPV-DNA定量及HPV E6/E7基因检测作为HPV感染的诊断依据和疗效评价指标。现阶段,治疗宫颈高危型HPV感染的方法主要有物理治疗、药物治疗、手术治疗及HPV疫苗干预等。由于HPV具有复杂的免疫逃逸机制,传统治疗方法存在治疗周期长、复发率高、需多次手术的不足,且可能发生宫颈机能不全及流产等并发症。本研究就近年来宫颈高危型HPV致病机制与治疗进展进行综述,为临床提供新的诊疗思路。
Human papillomavirus(HPV)is a small,non enveloped circular double stranded DNA virus with special epitheliophilicity,which is one of the common sexually transmitted diseases in women.Currently,more than 200 different HPV genotypes have been discovered.Persistent high-risk HPV infection is closely related to cervical and vaginal intraepithelial neoplasia and cervical cancer,and lacks typical clinical symptoms in the early stages,seriously endangering women's health.The latest research uses HPV DNA quantification and HPV E6/E7 gene testing as diagnostic criteria and efficacy evaluation indicators for HPV infection.At present,the main methods for treating high-risk cervical HPV infections include physical therapy,drug therapy,surgical treatment,and HPV vaccine intervention.Due to the complex immune escape mechanism of HPV,traditional treatment methods have shortcomings such as long treatment cycles,high recurrence rates,multiple surgeries,and the possibility of complications such as cervical dysfunction and miscarriage.This study reviews the pathogenesis and treatment progress of high-risk cervical HPV in recent years,providing new diagnostic and therapeutic ideas for clinical practice.
作者
许颖
佐满珍
黄凤
Xu Ying;Zuo Manzhen;Huang Feng(Department of Gynecology and Obstetrics,Three Gorges University People′s Hospital,Yichang 443000,China;Department of Gynecology and Obstetrics,Yichang Central People′s Hospital,Yichang 443000,China)
出处
《中国医师杂志》
CAS
2024年第8期1277-1280,F0003,共5页
Journal of Chinese Physician
基金
宜昌市2019年度科技计划项目(A19-301-27)。