白细胞介素6在炎症性肠病中的研究进展

Research progress of interleukin-6 in inflammatory bowel disease

炎症性肠病(IBD)是一种慢性自身免疫介导的炎性疾病,其病因、发病机制尚不明确,但普遍认为遗传、环境、免疫等多种因素参与了IBD的发生与发展,其中免疫调控的异常是IBD发生发展的中心环节。白细胞介素6(IL-6)是一种多效性细胞因子,可以调控先天性和获得性免疫反应,是机体在发生炎症反应时的重要调节因子。本文就IL-6在IBD病程进展及治疗中的作用进行综述,为临床决策提供依据。

Inflammatory bowel disease(IBD)is a chronic autoimmune-mediated inflammatory disease whose etiology and pathogenesis are not clear.It is generally believed that multiple factors such as genetics,environment and immunity are involved in the occurrence and development of IBD.Particularly,abnormal immune regulation is the central link in IBD progression.Interleukin-6(IL-6)is a pleiotropic cytokine regulating innate and acquired immune responses,and also an important regulator of the inflammatory response.This article reviews the role of IL-6 in the progression and treatment of IBD in order to provide a basis for clinical decision-making.