血清PCT、IL-6、hs-CRP、IgE表达水平在儿童支气管肺炎中的临床价值

Clinical value of serum PCT,IL⁃6,hs⁃CRP and IgE level in children with bronchopneumonia

目的探究血清降钙素原(PCT)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、免疫球蛋白E(IgE)水平在儿童支气管肺炎中的变化,及其联合检测对疾病的诊断价值。方法选择2020年10月-2022年10月如皋市人民医院门诊及住院的感染性支气管肺炎患儿95例作为观察组,同期医院儿科门诊体检健康儿童100名作为对照组。根据不同感染类型将观察组二次分组为病毒组(n=53)和细菌组(n=42);根据不同严重程度分为一般组(n=58)和严重组(n=37)。入组研究对象均需采集血清PCT、IL-6、hs-CRP、IgE含量,对比上述指标在不同分组中含量变化,并用受试者工作特征(ROC)曲线分析其对儿童支气管肺炎的诊断价值。结果观察组血清PCT、IL-6、hs-CRP、IgE水平均高于对照组,差异均有统计学意义(t=15.336、25.085、33.598、27.218,P均<0.05)。ROC曲线分析结果显示:血清PCT、IL-6、hs-CRP、IgE及指标联合预测概率曲线下面积(AUC)值依次为0.698(95%CI:0.611~0.785)、0.777(95%CI:0.701~0.854)、0.737(95%CI:0.655~0.820)、0.678(95%CI:0.592~0.764)、0.872(95%CI:0.814~0.929),单一因素AUC值均低于联合预测,差异有统计学意义(P<0.05)。病毒组患儿血清PCT、IL-6、hs-CRP含量均低于细菌组,差异均有统计学意义(t=18.967、13.145、31.697,P均<0.05)。一般组血清PCT、IL-6、hs-CRP、IgE含量均低于严重组,差异均有统计学意义(t=14.231、16.538、18.078、13.796,P均<0.05)。结论血清PCT、IL-6、hs-CRP、IgE检测结果联合可辅助诊断儿童支气管肺炎,且能在一定程度上反应病情变化。

Objective To explore the changes of serum levels of procalcitonin(PCT),interleukin⁃6(IL⁃6),high sensitivity C⁃reactive protein(hs⁃CRP),and immunoglobulin E(IgE)in children with bronchopneumonia,and the diagnostic value of their combination.Methods A total of 95 pediatric patients with infectious bronchopneumonia were selected as observation group from October 2020 to October 2022.Additionally,100 healthy children who underwent physical examinations in the Pediatric Outpatient Department of the hospital were selected as control group.Observation group was further divided into virus group(n=53),bacteria group(n=42);general group(n=58)and severe group(n=37).Serum levels of PCT,IL⁃6,hs⁃CRP,and IgE levels were determined in all research subjects and compared their changes in different groups;their diagnostic value for pediatric bronchopneumonia were analyzed using receiver operating characteristic(ROC)curves.Results The levels of PCT,IL⁃6,hs⁃CRP,and IgE in the serums of observation group were all significantly higher than those in the control group(t=15.336,25.085,33.598,27.218;all P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)values of serum PCT,IL⁃6,hs⁃CRP,IgE and joint index were 0.698(95%CI:0.611-0.785),0.777(95%CI:0.701-0.854),0.737(95%CI:0.655-0.820),0.678(95%CI:0.592-0.764),and 0.872(95%CI:0.814-0.929),respectively,with single factor AUC values lower than the joint prediction probability(P<0.05).The serum PCT,IL⁃6,and hs⁃CRP levels in the virus group were significantly lower than those in the bacterial group(t=18.967,13.145,31.697;all P<0.05).The serum levels of PCT,IL⁃6,hs⁃CRP,and IgE in the general group were significantly lower than those in the severe group(t=14.231,16.538,18.078,13.796;all P<0.05).Conclusion The combination of serum PCT,IL⁃6,hs⁃CRP,and IgE detection results could assist in the diagnosis of pediatric bronchopneumonia,and reflect the changes in the condition to a certain extent.