自体富血小板血浆滴眼液治疗干眼症的临床疗效观察

Clinical observation of autologous platelet-rich plasma eye drops in the treatment of dry eye syndrome

目的探讨采用自体富血小板血浆(platelet-rich plasma,PRP)治疗干眼症的疗效。方法随机选取2023年3-11月河北省京东中美医院眼科收治的64名干眼症患者进行临床研究。按照随机数字表法分为观察组和对照组,每组各32名64只眼。对照组予以不含防腐剂的聚乙烯醇人工泪液治疗,观察组应用自体PRP滴眼液治疗。比较2组患者的临床疗效及不良反应。观察比较了2组4周的总体疗效、症状消失时间和干眼量表评分(ocular surface disease index,OSDI)、泪膜破裂时间(tear break-up time,TBUT)、泪液分泌试验(schirmer’s test,St)及角膜荧光素染色(corneal_fluorescein_staining,CFS)和泪液高度5项疗效评估指标。结果患者治疗4周后,观察组患者治疗总有效率为96.88%(31/32),显著高于对照组患者84.38%(27/32),差异有统计学意义(P<0.05);治疗后,观察组患者St、TBUT、CFS、OSDI干眼量表评分、泪河高度水平均显著优于对照组,差异有统计学意义(P<0.05)。观察组干涩、视觉疲劳、异物感消失时间短于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为46.875%(15/32),与对照组比较差异无统计学意义。结论自体PRP可能是1种治疗干眼症有效、安全的优选手段,值得进一步研究证实。

Objective To explore the effect of autologous platelet-rich plasma(PRP)in the treatment of dry eye syndrome.Methods A total of 64 patients with dry eye treated in the Ophthalmology Department of Jingdong Sino-American Hospital of Hebei Province from March to November 2023 were randomly selected for the study.The patients were divided into observation group and control group according to the random number table method,with 32 cases and 64 eyes in each group.The control group was treated with artificial tears of polyvinyl alcohol without preservatives,and the observation group was treated with PRP eye drops.The clinical efficacy and adverse reactions of the two groups were compared.Overall efficacy,duration of symptom resolution,ocular surface disease index(OSDI),tear film break up time(TBUT),schirmer's test(St)and corneal fluorescein staining(CFS)results of the two groups were observed and compared in 4 weeks.Results After 4 weeks of treatment,the total effective rate of observation group was 96.88%(31/32),which was significantly higher than that of control group 84.38%(27/32),with statistical significance(P<0.05).After treatment,the St,TBUT,CFS,OSDI and lacrimal river height in observation group were significantly superior to control group,with statistical significance(P<0.05).The disappearance time of dryness,visual fatigue and foreign body sensation in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 46.875%(15/32),and there was no significant difference between the observation group and the control group.Conclusion Autologous PRP is an effective and safe choice for the treatment of dry eye syndrome,which is worthy of further study and confirmation.