摘要
目的:系统评价青蒿鳖甲汤(QHBJD)治疗癌性发热的疗效和安全性。方法:计算机检索中国知网等八个大型数据库,搜集关于青蒿鳖甲汤治疗癌性发热的随机对照试验(randomized controlled trial,RCT)。在获取资料后进行meta分析。结果:共纳入23个RCT实验,2002例患者,Meta分析结果显示结果显示在有效率方面青蒿鳖甲汤组的退热有效率高于单纯西药组(P<0.05)。青蒿鳖甲汤组对于癌性发热的治愈率高于单纯西药组(P<0.05)。蒿鳖甲汤组治疗癌性发热不良反应低于单纯西药组(P<0.05)。青蒿鳖甲汤组相比较单纯西药组可以更大程度上改善炎症反应,降低白细胞计数(P<0.05)。结论:青蒿鳖甲汤对于癌因性发热治疗的有效率治愈率皆高于单纯西药,同时不良反应低于对照组,青蒿鳖甲汤可以显著降低白细胞计数,改善患者炎症状态。
Objective:To systematically evaluate the efficacy and safety of Qinghao Biejia Decoction(QHBJD)in the treatment of cancer fever.Methods:Eight large databases including CNKI were searched by computer to collect randomized controlled trials(RCTs)on the treatment of cancer fever with Qinghao Biejia Decoction.Meta-analysis was performed after obtaining the data.Results:A total of 23 RCT experiments with 2002 patients were included.The metaanalysis results showed that the effective rate of Qinghao Biejia Decoction group was higher than that of the Western medicine group(P<0.05).The cure rate of cancer fever in the Qinghao Biejia Decoction group was higher than that in the Western medicine group(P<0.05).The adverse reactions of the treatment of cancer fever in the Hao Biejia Decoction group were lower than those in the Western medicine group(P<0.05).The Qinghao Biejia Decoction group could improve the inflammatory response and reduce the white blood cell count to a greater extent than the Western medicine group(P<0.05).Conclusion:The effective rate and cure rate of Qinghao Biejia Decoction in the treatment of cancerrelated fever are higher than those of Western medicine alone,and the adverse reactions are lower than those of the control group.Qinghao Biejia Decoction can significantly reduce the white blood cell count and improve the inflammatory state of patients.
作者
张宸
董胡可
张东伟
ZHANG Chen;DONG Huke;ZHANG Dongwei(Anhui University of Chinese Medicine,Anhui Hefei 230012,China;Anhui Medical University,Anhui Hefei 230032,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)
出处
《中医药临床杂志》
2024年第9期1719-1727,共9页
Clinical Journal of Traditional Chinese Medicine
基金
全国中医临床特色技术传承骨干人才培训项目(编号:国中医药人教函〔2019〕36号)
安徽省十三五重点专科(ZLK20190054)。
关键词
青蒿鳖甲汤
癌性发热
META分析
随机对照实验
Qinghao Biejia Decoction
Cancer-related fever
Meta-analysis
Randomized controlled trial