5-氨基酮戊酸光动力疗法及CO_(2)激光分别联合复方利多卡因凝胶治疗尖锐湿疣的疗效及复发的相关性分析

Correlation analysts of the efficacy and recurrence of 5-aminolevulinic acid photodynamic therapy and carbon dioxide laser separately combined with compound lidocainc gel in the treatment of condyloma acuminatum

目的探讨5-氨基酮戊酸光动力疗法(ALA-PDT)及二氧化碳(CO_(2))激光分别联合复方利多卡因凝胶治疗尖锐湿疣(CA)的疗效及复发的相关性分析。方法回顾性分析2021年1月至2023年1月徐州医科大学附属医院收治的121例CA患者的临床资料,根据治疗方式分为A组(n=62)、B组(n=59),A组采用ALA-PDT联合复方利多卡因凝胶治疗,B组采用CO_(2)激光联合复方利多卡因凝胶治疗,比较两组的临床疗效。治疗后6个月随访统计复发情况,并将患者分为复发组(n=34)和未复发组(n=87),分析CA患者复发的影响因素。结果A组临床总有效率高于B组,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,多发CA、偶尔/经常使用或不使用安全套、2名及以上性伴侣、经常熬夜、CO_(2)激光联合复方利多卡因凝胶治疗是CA患者复发的独立危险因素(P<0.05)。结论ALA-PDT联合复方利多卡因凝胶治疗CA的疗效优于CO_(2)激光联合复方利多卡因凝胶治疗,CA数目、安全套使用情况、性伴侣数量、经常熬夜及治疗方式等是CA患者复发的相关因素,临床需重视以上因素并制定针对性干预措施以降低CA复发率。

Objective To investigate the efficacy and recurrence of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)and carbon dioxide(CO_(2))laser separately combined with compound lidocaine gel in the treatment of condyloma acuminatum(CA).Methods The clinical data of 121 patients with CA admitted to Affiliated Hospital of Xuzhou Medical University from January 2021 to January 2023 were retrospectively analyzed and divided into group A(n=62)and group B(n=59)according to the treatments.Group A was treated with ALA-PDT combined with compound lidocaine gel,and Group B was treated with CO_(2) laser combined with compound lidocaine gel.The clinical effects of the two groups were compared.Six months after the treatments,patients were followed up and divided into relapse group(n=34)and non-relapse group(n=87).The related factors of the recurrence in CA patients were analyzed.Results The total effective rate of Group A was better than that of Group B with statistically significant difference(P<0.05).Multivariate Logistic regression analysis showed that multiple CA,occasional/frequent condom using or not using condom,two or more sexual partners,frequent staying up late and CO_(2) laser combined compound lidocaine gel therapy were independent risk factors for the recurrence of CA patients(P<0.05).Conclusions The efficacy of ALA-PDT combined with compound lidocaine gel is better than CO_(2) laser combined with compound lidocaine gel in the treatment of CA.The number of CA,condom use condition,the number of sexual partners,frequent staying up late and treatment methods are the related factors of the recurrence of CA patients.Clinically,we should pay attention to the above factors and formulate targeted intervention measures to reduce the recurrence rate of CA.