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定量脑电图在神经和精神疾病辅助诊疗方面的应用进展

Application progress of quantitative electroencephalography in auxiliary diagnosis and treatment of neuropsychiatric diseases
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摘要 大脑控制着人体内各项高级神经活动,大脑的结构异常或功能紊乱会诱发多种神经和精神疾病。目前,神经系统疾病及精神疾病的发病机制仍未完全明确,临床诊断及预后评估尚缺乏客观、精准的定量指标。脑电图是神经和精神疾病常用的检测技术之一,而定量脑电图可以深入分析脑电信号的神经生理特征,为进一步阐明神经和精神疾病的病理机制和探索发现潜在的生物学标志物提供了手段。笔者综述了近年来定量脑电图在神经系统疾病和精神疾病辅助诊疗中的研究进展,介绍了定量脑电图分析的基本原理,总结了常见神经系统疾病(阿尔兹海默病、帕金森病)和精神疾病(精神分裂症)的定量脑电图研究成果。此外,神经及精神疾病的定量脑电图研究普遍存在样本量少、结果普适性差等局限性,采用数据增强技术提高样本量、结合神经影像数据进行多模态分析是未来研究的主要趋势。
作者 李嘉欣 熊冬生 吴凯 李懿 李文豪 周静 林岚(审校) LI Jia-xin;XIONG Dong-sheng;WU Kai;LI Yi;LI Wen-hao;ZHOU Jing(School of Material Science and Engineering,South China University of Technology,Guangzhou510006,Guangdong,China;National Engineering Research Center for Tissue Restoration and Reconstruction·Guangdong Province Key Laboratory of Biomedical Engineering,South China University of Technology,Guangzhou510006,Guangdong,China;School of Biomedical Sciences and Engineering,South China University of Technology,Guangzhou511442,Guangdong,China;Guangdong Engineering Technology Research Center for Translational Medicine of Mental Diseases,Guangzhou510370,Guangdong,China;Guangdong Engineering Technology Research Center for Diagnosis and Rehabilitation of Dementia,Guangzhou510500,Guangdong,China;School of Automation Science&Engineering,South China University of Technology,Guangzhou510640,Guangdong,China)
出处 《生物医学工程与临床》 CAS 2024年第5期725-734,共10页 Biomedical Engineering and Clinical Medicine
基金 广东省重点领域研发计划项目(2020B0404010002) 国家自然科学基金资助项目(72174082) 广东省基础与应用基础研究基金杰出青年项目(2021B1515020064) 广东省基础与应用基础研究基金资助项目(2022A1515140142) 广东省普通高校重点实验室项目(2020KSYS001) 广州市科技计划资助项目(202103000032,202206060005,202206080005,202206010077,202206010034)。
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