腹泻动物模型及治疗药物研究进展

Research progress in diarrhea animal models and drug therapies

腹泻是临床常见并且多发的疾病,引发腹泻的因素也比较多,目前有关腹泻动物模型的研究方法也比较多,但在临床上治疗腹泻的药物种类有限,现有的一部分药物也只适用于单一因素的腹泻。因此构建及选择合适的腹泻动物模型不仅是深入研究腹泻发病机制的重要基础,也是临床筛选和评价全面防治腹泻药物的有效手段。本文综述功能性、细菌性、病毒性、症状性腹泻动物模型的建立和评价以及治疗药物研究进展,以期为腹泻有关的动物实验研究和药物防治提供参考依据。

Diarrhea is a common and frequent disease in clinical practice.Many factors cause diarrhea,and numerous research method with animal models of diarrhea have been explored.Despite this,drugs for the treatment of diarrhea in clinical practice are limited,and some existing drugs are only suitable for diarrhea caused by a single factor.Therefore,the construction and selection of appropriate animal models of diarrhea are not only important for in-depth studies of the pathogenesis,but are also effective means for the clinical screening and evaluation of drugs for comprehensively preventing and treating diarrhea.This article reviews the literature on the establishment and evaluation of animal models of functional,bacterial,viral,and symptomatic diarrhea,as well as progress of therapeutic drug research,to provide a reference for animal experimental research into the prevention and treatment of diarrhea.