玉屏风配方颗粒联合加巴喷丁对维持性血液透析皮肤瘙痒症患者的临床价值

Clinical value of Yupingfeng Formula Granules combined with Gabapentin in patients with pruritus of skin on maintenance hemodialysis

目的探讨玉屏风配方颗粒联合加巴喷丁对维持性血液透析(MHD)皮肤瘙痒症患者的临床价值。方法选取2023年5月至10月九江市第三人民医院收治的60例MHD皮肤瘙痒症患者作为研究对象,根据随机数字表法分为观察组(30例)和对照组(30例)。两组均行常规血液透析和西医基础治疗,对照组口服加巴喷丁胶囊治疗,观察组加服玉屏风配方颗粒治疗,均持续用药8周。比较两组的临床疗效、血清免疫功能指标以及炎症因子水平。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗前T淋巴细胞、免疫球蛋白及C反应蛋白(CRP)和白介素(IL-6)水平比较,差异无统计学意义(P>0.05);两组治疗后T淋巴细胞及免疫球蛋白水平高于治疗前,且观察组高于对照组,CRP、IL-6水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论MHD皮肤瘙痒症患者应用玉屏风配方颗粒联合加巴喷丁治疗效果较佳,利于增强机体免疫力,缓解瘙痒症状,减轻炎症反应,值得临床推广。

Objective To explore the clinical value of Yupingfeng Formula Granules combined with Gabapentin in patients with of skin on maintenance hemodialysis(MHD).Methods A total of 60 patients with MHD skin pruritis admitted to the Jiujiang Third People's Hospital from May to October 2023 were selected as the research objects.According to the random number table method,they were divided into the observation group(30 cases)and the control group(30 cases).Both groups received routine hemodialysis and basic western medicine treatment,the control group was treated with oral Gabapentin Capsules,and the observation group was treated with Yupingfeng Formula Granules for 8 weeks.The clinical efficacy,serum immune function indexes and levels of inflammatory factors were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no significant differences in T lymphocyte,immunoglobulin,C-reactive protein(CRP)and interleukin(IL-6)levels between the two groups before treatment(P>0.05).The T lymphocyte and immunoglobulin levels after treatment were higher than those before treatment,and observation group were higher than those in control group,CRP and IL-6 levels were lower than those before treatment,and observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion The treatment effect of Yupingfeng Formula Granules combined with Gabapentin in MHD patients with skin pruritus is better,which is conducive to enhancing body immunity,relieving pruritus symptoms and reducing inflammation,and is worthy of clinical promotion.