膳食干预改善高脂膳食诱导肥胖小鼠的脂代谢异常和脏器损伤

Dietary Intervention Improves Lipid Metabolism Abnormalities and Organ Damage in Obese Mice Induced by High-Fat Diet

此研究旨在探究膳食干预对高脂饮食小鼠的影响,以海信爱家APP的膳食管家平台中典型的减肥菜品鸡胸沙拉、清炒芥蓝、时蔬沙拉和香菇青菜为代表,评估长期摄入减肥食谱食物对高脂饮食小鼠体重、脂质代谢及炎症因子的影响。研究结果表明,膳食干预可以有效抑制高脂饮食引起的小鼠肥胖,其中香菇青菜组和清炒芥蓝组显著降低高脂饮食小鼠的体重和脏器指数(P<0.05)。此外,膳食干预还改善高脂饮食小鼠血脂代谢异常,降低血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量,同时增加血清中高密度脂蛋白胆固醇(HDL-C)含量。H&E染色和ELISA的结果表明,膳食干预减轻了高脂饲料引起的结肠和肝脏相关的炎症,香菇青菜组和清炒芥蓝组不仅抑制了高脂饮食引起的肝脏和结肠损伤,还可以显著降低肝脏中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-1β(IL-1β)的含量(P<0.05)。这些结果为膳食干预治疗慢性肥胖病提供了一定的理论支持和优化建议。

The aim of this study was to explore the effects of dietary intervention on mice with high-fat diet.The typical weight-loss dishes in the Meal Manager platform of Hisense AiJia APP were represented,including chicken breast salad,sauteed kale,vegetable salad,and sauteed greens with mushrooms.The effects of these weight loss recipe foods on body weight,lipid metabolism and inflammatory factors were assessed by long-term intake in high-fat diet mice.The results showed that the dietary intervention could effectively inhibit high-fat diet-induced obesity in mice,in which the sauteed green with mushroom group and sauteed kale group significantly reduced the body weight and organ index of high-fat diet mice(P<0.05).In addition,the dietary intervention improved dyslipidemia in high-fat diet mice,reducing serum levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C),while increasing serum levels of high-density lipoprotein cholesterol(HDL-C).The results of H&E staining and ELISA indicated that the dietary intervention attenuated high-fat diet-induced attenuated high-fat diet-induced colon-and liver-associated inflammation,and that the sauteed green with mushroom group and sauteed kale group not only inhibited high-fat diet-induced liver and small intestinal injury,but also significantly reduced tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-1β(IL-1β)levels in the liver(P<0.05).These results could provide some theoretical support and optimization suggestions for dietary intervention in treating chronic obesity.