加味活络效灵丹联合常规化疗治疗气滞血瘀型结直肠癌疗效观察

Clinical Curative Observation of Modified Huoluo Xiaoling Pill with Conventional Chemotherapy in the Treatment of Colorectal Cancer with Blood Stasis Due to Qi Stagnation

目的:探究加味活络效灵丹联合常规化疗治疗气滞血瘀型结直肠癌的临床疗效及安全性评价。方法:选取江西中医药大学附属医院2021年9月—2023年9月收治的符合纳入标准的88例气滞血瘀型结直肠癌患者为观察对象,采用随机分组法随机分成观察组(n=43)和对照组(n=45)。观察组以加味活络效灵丹联合常规化疗方案进行治疗,对照组仅以常规化疗方案进行治疗。观察2组患者治疗前后实验室指标(包括血常规、凝血功能、肝肾功能、肿瘤指标等)、中医证候积分、评分的变化以及中医临床疗效、客观临床疗效等。结果:2组患者治疗前后比较、治疗后组间比较,血红蛋白、白细胞、血小板、白蛋白和肌酐水平差异均无统计学意义(P>0.05)。治疗后,观察组D-二聚体水平改善情况优于对照组(P<0.05);2组癌胚抗原、糖类抗原199水平均有降低,且观察组低于对照组,差异均有统计学意义(P<0.05);观察组中医证候积分显著低于对照组,且观察组中医证候总有效率为60.46%,高于对照组的35.55%,差异均有统计学意义(P<0.05);临床客观疗效方面,观察组疾病控制率为69.77%,高于对照组的48.89%,差异有统计学意义(P<0.05)。2组患者客观缓解率比较无显著性差异(P>0.05)。结论:加味活络效灵丹联合化疗治疗结直肠癌较单纯化疗更具优势,能降低患者中医证候积分和D-二聚体、肿瘤相关标志物水平,改善患者体力状况,提高其生活质量。

Objective:Explore Modified Huoluo Xiaoling Pill combined with conventional chemotherapy effect best treatment of blood stasis due to Qi stagnation type to colorectal cancer clinical curative efficacy and safety.Methods:Choose between September 2021 and September 2023,88 cases hospitalized in the affiliated hospital of jiangxi university of Chinese medicine and standard for clinical observation and colorectal cancer patients.Using the randomization method fall into observation group(n=43)and control group(n=45).Observation group with Modified Huoluo Xiaoling Pill joint standard chemotherapy regimens for treatment,control group was treated with standard chemotherapy regimens.The changes of laboratory indicators(including blood routine,coagulation function,liver and kidney function,tumor indicators),TCM syndrome score,TCM clinical efficacy,KPS score,and objective clinical efficacy before and after treatment in the two groups were observed.Results:There was no significant variation in hemoglobin,white blood cell,platelet level albumin and creatinine between the two groups before and after treatment(P>0.05).Improvement in D-2 polymer levels in the observation group was better than that in the control group(P<0.05).Posttreatment CEA and CA199 levels were decreased in both groups(P<0.05),and the reduction level in observation group was significantly better than that in control group(P<0.05).The TCM syndrome score of the experimental group was clearly lower than that of the matched group(P<0.05),and the total effective rate of TCM syndrome in the observation group was 60.46%,which was clearly higher than that of the control group 35.55%(P<0.05).On the part of clinical impersonal efficacy,the disease control rate of the observation group was 69.77%,which was clearly higher than that of the control group 48.89%,with statistically signifilcant differences(P<0.05).There was no noteworthy discrepancy in the objective response rate between the two groups(P>0.05).Conclusion:Modified Huoluo Xiaoling Pill combined with chemotherapy has more advantages than chemotherapy alone in the treatment of colorectal cancer,which can reduce the levels of traditional Chinese medicine symptoms,D-2 polymers and tumor-related markers,improve physical condition and improve quality of life.