基于“穴位敏化理论”探讨针刺内关穴治疗慢性冠脉综合征的效应机制

Exploring Effect Mechanism of Needling PC6 for Treatment of CCS Based on Acupoint Sensitization Theory

慢性冠脉综合征(CCS)是冠心病(CAD)的主要类型之一,症状以胸闷、胸痛和呼吸困难为主,反映了动脉粥样硬化斑块积聚和冠状动脉循环功能改变的动态过程,久病累积多个系统,严重影响人体健康。世界卫生组织将冠心病列为推荐进行针刺治疗的疾病之一。近年来随着研究的深入,学者发现心肌缺血时,以内关穴为代表的相关穴位会出现明显的敏化现象。针刺敏化态穴位如内关穴可以更好地调节神经系统,影响相关信号物质和离子通道,增强心脏的自我修复功能,故而内关穴被视为慢性冠脉综合征穴敏现象在临床治疗中的代表性穴位。本研究通过总结针刺治疗慢性冠脉综合征的效应机制,进一步探讨了穴位敏化理论与其机制的相关性,以期为后续研究提供理论依据。

Chronic coronary syndrome(CCS)is one of the main types of coronary artery disease(CAD),with symptoms of chest tightness,chest pain,and dyspnea as the main symptoms,reflecting the dynamic process of atherosclerotic plaque buildup and coronary artery circulatory function alteration,and the involvement of multiple systems over a long period of time,which seriously affects the health of the human body.The World Health Organization has listed coronary heart disease as one of the diseases recommended for acupuncture treatment.In recent years,with the deepening of research,many scholars have discovered that myocardial ischemia leads to significant sensitization phenomena at related acupoints,such as Neiguan(PC6).Needling sensitized acupoints like PC6 can better regulate the nervous system,influence related signaling substances and ion channels,and enhance the heart's self-repair functions.Therefore,PC6 is considered as a representative acupoint for the phenomenon of acupoint sensitization in the clinical treatment of CCS.This study summarizes the effect mechanisms of acupuncture in the treatment of CCS and further explores the correlation between acupoint sensitization theory and its mechanisms,providing a theoretical basis for future researches.