重组牛碱性成纤维细胞生长因子滴眼液联合双氯芬酸钠滴眼液治疗睑板腺功能障碍所致蒸发过强型干眼症患者的效果

Effects of recombinant bovine basic fibroblast growth factor eye drops combined with Diclofenac sodium eye drops in treatment of patients with evaporative dry eye caused by meibomian gland dysfunction

目的:观察重组牛碱性成纤维细胞生长因子滴眼液联合双氯芬酸钠滴眼液治疗睑板腺功能障碍所致蒸发过强型干眼症患者的效果。方法:回顾性分析2021年1月至2023年8月该院收治的60例睑板腺功能障碍所致蒸发过强型干眼症患者的临床资料,按照治疗方法不同将其分为对照组和观察组各30例。两组均予以生理盐水雾化治疗,在此基础上,对照组采用双氯芬酸钠滴眼液治疗,观察组在对照组基础上联合重组牛碱性成纤维细胞生长因子滴眼液治疗,两组均连续治疗2周。比较两组临床疗效,治疗前后临床症状[眼表疾病指数量表(OSDI)]评分、泪膜功能指标[泪膜破裂时间(BUT)、泪液分泌试验(SIT)]水平,以及不良反应发生率。结果:观察组治疗总有效率为93.33%(28/30),高于对照组的70.00%(21/30),差异有统计学意义(P<0.05);治疗后,观察组OSDI评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组BUT、SIT值均大于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组牛碱性成纤维细胞生长因子滴眼液联合双氯芬酸钠滴眼液治疗睑板腺功能障碍所致蒸发过强型干眼症患者可提高治疗总有效率,降低临床症状评分,改善泪膜功能指标水平,效果优于单纯双氯芬酸钠滴眼液治疗。

Objective:To observe effects of recombinant bovine basic fibroblast growth factor eye drops combined with Diclofenac sodium eye drops in treatment of patients with evaporative dry eye caused by meibomian gland dysfunction.Methods:The clinical data of 60 patients with evaporative dry eye caused by meibomian gland dysfunction admitted to this hospital from January 2021 to August 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each group.Both groups were treated with Saline atomization.On this basis,the control group was treated with Diclofenac sodium eye drops,while the observation group was treated with recombinant bovine basic fibroblast growth factor eye drops on the basis of that of the control group.Both groups were treated for 2 weeks.The clinical efficacy,the clinical symptoms[ocular surface disease index(OSDI)]score,the tear film function indexes[tear film break-up time(BUT),tear secretion test(SIT)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.33%(28/30),which was higher than 70.00%(21/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the OSDI score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the BUT and SIT values of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Recombinant bovine basic fibroblast growth factor eye drops combined with Diclofenac sodium eye drops in the treatment of the patients with evaporative dry eye caused by meibomian gland dysfunction can improve the total effective rate of treatment,reduce the clinical symptom scores,and improve the levels of tear film function indexes.Moreover,it is superior to simple Diclofenac sodium eye drops treatment.